American Journal of Psychiatry

Disruptive mood dysregulation disorder (DMDD), a newcomer to psychiatric nosology, addresses the need for improved classification and treatment of children exhibiting chronic nonepisodic irritability and severe temper outbursts. In recent years, many of ...

https://doi.org/10.1176/appi.ajp.2014.13101301

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Perspectives

Perspectives in Global Mental Health

Major Depression in Postconflict Northern Uganda: A Case Report

Publication date: 01 September 2014

Pages925–928https://doi.org/10.1176/appi.ajp.2014.14020261

Perspectives

Images in Psychiatry

Wandering or Unhappy Mind?

Ladislav Kesner, Ph.D.

Publication date: 01 September 2014

Pages929–930https://doi.org/10.1176/appi.ajp.2013.13121629

Perspectives

Reviews and Overviews

The Structure of Psychiatric Science

Kenneth S. Kendler, M.D.

Publication date: 01 September 2014

Pages931–938

This essay explores the etiology of psychiatric disorders across biological, psychological, and environmental risk factors, and outlines three central paradigms for risk analysis, mechanisms of illness, and first-person approaches to patient empathy.

https://doi.org/10.1176/appi.ajp.2014.13111539

New Research

Articles

Cortical Thinning, Functional Connectivity, and Mood-Related Impulsivity in Schizophrenia: Relationship to Aggressive Attitudes and Behavior

Publication date: 01 September 2014

Pages939–948

A robust association was found in patients with schizophrenia between cortical thinning in ventral prefrontal regions and increased impulsivity, which likely reflects an impaired interaction with regions affecting cognitive control regions. As urgency ...

https://doi.org/10.1176/appi.ajp.2014.13111553

Reading Deficits in Schizophrenia and Individuals at High Clinical Risk: Relationship to Sensory Function, Course of Illness, and Psychosocial Outcome

Publication date: 01 September 2014

Pages949–959

ObjectiveThe ability to read passages of information fluently and with comprehension is a basic component of socioeconomic success. Reading ability depends on the integrity of underlying visual and auditory (phonological) systems. This study investigated ...

https://doi.org/10.1176/appi.ajp.2014.13091196

Elevated Maternal C-Reactive Protein and Increased Risk of Schizophrenia in a National Birth Cohort

Publication date: 01 September 2014

Pages960–968

Maternal inflammation level during pregnancy was related to risk of schizophrenia in offspring, adding new evidence for the association of infection and immune activation with the development of the disorder.

https://doi.org/10.1176/appi.ajp.2014.13121579

Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268

Publication date: 01 September 2014

Pages969–978

ObjectiveCognitive deficits of schizophrenia may be due at least in part to lower expression of the 67-kDa isoform of glutamic acid decarboxylase (GAD67), a key enzyme for GABA synthesis, in the dorsolateral prefrontal cortex of individuals with ...

https://doi.org/10.1176/appi.ajp.2014.14010004

Effects of Schizophrenia Risk Variation in the NRG1 Gene on NRG1-IV Splicing During Fetal and Early Postnatal Human Neocortical Development

Publication date: 01 September 2014

Pages979–989

Mapping the transcriptional and genetic regulation of NRG1s during normal human brain development could help identify a potential mechanism of early risk for schizophrenia at the NRG1 locus.

https://doi.org/10.1176/appi.ajp.2014.13111518

Longitudinal Trajectories and Associated Baseline Predictors in Youths With Bipolar Spectrum Disorders

Publication date: 01 September 2014

Pages990–999

ObjectiveThe authors sought to identify and evaluate longitudinal mood trajectories and associated baseline predictors in youths with bipolar disorder.MethodA total of 367 outpatient youths (mean age, 12.6 years) with bipolar disorder with at least 4 ...

https://doi.org/10.1176/appi.ajp.2014.13121577