American Journal of Psychiatry
- Volume 176
- Number 10
- October 2019
Editor’s NOTE
Editorials
Treatment in Psychiatry
Reviews and Overviews
Publication date: 01 October 2019
Pages794–810Scientific progress in understanding human disease can be measured by the effectiveness of its treatment. Antipsychotic drugs have been proven to alleviate acute psychotic symptoms and prevent their recurrence in schizophrenia, but the outcomes of most ...
https://doi.org/10.1176/appi.ajp.2019.19080865Articles
Publication date: 01 July 2019
Pages811–819Objective: Schizophrenia is associated with a marked cognitive impairment that is widely believed to remain stable after illness onset. Yet, to date, 10-year prospective studies of cognitive functioning following the first episode with good methodology are ...
https://doi.org/10.1176/appi.ajp.2019.18091088Publication date: 24 June 2019
Pages820–828Objective: Detecting brain abnormalities in clinical high-risk populations before the onset of psychosis is important for tracking pathological pathways and for identifying possible intervention strategies that may impede or prevent the onset of psychotic ...
https://doi.org/10.1176/appi.ajp.2019.18091044Publication date: 29 July 2019
Pages829–838Objective: Failure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes of treatment resistance are unknown, but it is associated with earlier age at ...
https://doi.org/10.1176/appi.ajp.2019.18101212Publication date: 01 July 2019
Pages839–845Objective: The early course of illness in psychotic disorders is highly variable, and predictive biomarkers of treatment response have been lacking. Trial and error remains the basis for care in early psychosis, and poor outcomes are common. Early ...
https://doi.org/10.1176/appi.ajp.2019.18101126Publication date: 16 August 2019
Pages846–855Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but few validated risk predictors are available. Genetic profiling is one approach to risk stratification that has been extensively validated in research cohorts. ...
https://doi.org/10.1176/appi.ajp.2019.18091085Letters to the Editor
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