American Journal of Psychiatry
- Volume 155
- Number 9
- September 1998
Editorial
Images In Neuroscience
Special Article
Publication date: 01 September 1998
Pages1152–1162Objective: With recent advances in molecular genetics, the rate-limiting step in identifying susceptibility genes for psychiatric disorders has become phenotype definition. The success of psychiatric genetics may require the development of a “genetic ...
https://doi.org/10.1176/ajp.155.9.1152Regular Article
Publication date: 01 September 1998
Pages1163–1171Objective: There has been considerable controversy regarding the impact of the Holocaust on the second generation, but few empirical data are available that systematically document trauma exposure and psychiatric disorder in these individuals. To obtain ...
https://doi.org/10.1176/ajp.155.9.1163Publication date: 01 September 1998
Pages1172–1177Objective: The role of group therapy in treatment of posttraumatic stress disorder (PTSD) has been traditionally restricted to issues of self-esteem and interpersonal relationships, rather than primary symptoms of the disorder. In this study, the authors ...
https://doi.org/10.1176/ajp.155.9.1172Publication date: 01 September 1998
Pages1178–1183Objective: This study was undertaken to clarify earlier inconsistent findings in brain metabolic topography in panic disorder patients at rest.Method: Positron emission tomography (PET) with [18F]fluorodeoxyglucose was used to determine cerebral metabolic ...
https://doi.org/10.1176/ajp.155.9.1178Publication date: 01 September 1998
Pages1184–1188Objective: The authors investigated the role of genetic factors in 35% CO2-induced panic attacks.Method: Ninety twins recruited from general population were challenged with one-vital capacity inhalations of 35% CO2–65% O2. Probandwise concordance rates ...
https://doi.org/10.1176/ajp.155.9.1184Publication date: 01 September 1998
Pages1189–1195Objective: This study determined the efficacy and safety of sertraline in the treatment of patients with panic disorder. Method: The study was a randomized, double-blind, parallel-group, flexible-dose comparison of sertraline and placebo in outpatients ...
https://doi.org/10.1176/ajp.155.9.1189Publication date: 01 September 1998
Pages1196–1201Objective: Many studies have validated the grouping of schizophrenic symptoms into three independent dimensions: negative, psychotic, and disorganized. Negative symptoms are considered to be an important prognostic indicator, but this clinical observation ...
https://doi.org/10.1176/ajp.155.9.1196Publication date: 01 September 1998
Pages1202–1206Objective: This study investigated the rate of spontaneous abnormal involuntary movements in a group of patients presenting with a first episode of schizophrenia or schizophreniform psychosis. Method: Seventy-nine patients with a first episode of ...
https://doi.org/10.1176/ajp.155.9.1202Publication date: 01 September 1998
Pages1207–1213Objective: Tardive dyskinesia is a movement disorder affecting 20%–40% of patients treated chronically with neuroleptic drugs. The dopamine supersensitivity hypothesis cannot account for the time course of tardive dyskinesia or for the persistence of ...
https://doi.org/10.1176/ajp.155.9.1207Publication date: 01 September 1998
Pages1214–1220Objective: The authors investigated whether nonpsychotic relatives of schizophrenic probands have an elevated risk of deficits in sustained attention as measured by the Continuous Performance Test (CPT), whether such deficits are associated with specific ...
https://doi.org/10.1176/ajp.155.9.1214Publication date: 01 September 1998
Pages1221–1226Objective: Patients with the deficit syndrome differ from other patients with schizophrenia relative to physiological correlates, course of illness, and response to treatment. Because of the abnormal seasonality of birth among persons with schizophrenia, ...
https://doi.org/10.1176/ajp.155.9.1221Publication date: 01 September 1998
Pages1227–1233Objective: Study 1 evaluated whether pregnancy is a stressful life event for teenagers and is associated with depression for teenagers with a pessimistic attributional style but not for those with an optimistic attributional style. Study 2 replicated ...
https://doi.org/10.1176/ajp.155.9.1227Publication date: 01 September 1998
Pages1234–1240Objective: While family and twin studies suggest that retrospectively reported premenstrual symptoms are heritable, these studies have not accounted for the unreliability of such measures. In addition, we know little about the relationship of the familial ...
https://doi.org/10.1176/ajp.155.9.1234Publication date: 01 September 1998
Pages1241–1246Objective: Subnormal prolactin responses to the serotonin-releasing agonist fenfluramine occur in depression. Since many measures of serotonin pathology occur in depression, abnormal responses to fenfluramine may occur in brain structures other than the ...
https://doi.org/10.1176/ajp.155.9.1241Publication date: 01 September 1998
Pages1247–1253Objective: The purpose of this study was to determine prospectively the optimal length of therapy in a long-term, placebo-controlled continuation study of patients who responded to acute fluoxetine treatment for major depression (defined by DSM-III-R). ...
https://doi.org/10.1176/ajp.155.9.1247Publication date: 01 September 1998
Pages1254–1260Objective: The purpose of this study was to determine what predicts patients’ perceptions of coercion surrounding admission to a psychiatric hospital.Method: For 171 cases, the authors integrated data from interviews with patients, admitting clinicians, ...
https://doi.org/10.1176/ajp.155.9.1254Publication date: 01 September 1998
Pages1261–1264Objective: This article brings to the present earlier bibliographies of books written by former mental patients. These books provide an inside view of mental disorder that can be useful in teaching, public education, theory, and research, and they have ...
https://doi.org/10.1176/ajp.155.9.1261Clinical Case Conference
Images In Psychiatry
Brief Report
Publication date: 01 September 1998
Pages1275–1277Objective: The molecular basis of neuroleptic malignant syndrome is unclear, but studies suggest that genetic factors are involved in its pathogenesis. Considering possible involvement of the serotonergic system in neuroleptic malignant syndrome, the ...
https://doi.org/10.1176/ajp.155.9.1275Publication date: 01 September 1998
Pages1278–1280Objective: The authors conducted a pilot study to develop preliminary data on the frequency of cytochrome P450-2D6 (CYP2D6) genotypes in state psychiatric hospital patients and to establish population sizes needed to determine potential clinical relevance ...
https://doi.org/10.1176/ajp.155.9.1278Publication date: 01 September 1998
Pages1281–1284Objective: The mismatch negativity, a negative component in the auditory event-related potential, is thought to index automatic processes involved in sensory or echoic memory. The authors’ goal in this study was to examine the topography of auditory ...
https://doi.org/10.1176/ajp.155.9.1281Publication date: 01 September 1998
Pages1285–1287Objective: Hypofrontality is a common but not invariable finding in schizophrenia. Inconsistencies in the literature may reflect, in part, the fact that abnormal physiological responses in the prefrontal cortex are best identified under conditions that ...
https://doi.org/10.1176/ajp.155.9.1285Publication date: 01 September 1998
Pages1288–1290Objective: The authors’ goal was to compare the size and linear density of Purkinje cells in the cerebellar vermis of subjects with and without schizophrenia. Method: Blocks of alcohol-fixed cerebellar vermis were dissected at autopsy from the brains of ...
https://doi.org/10.1176/ajp.155.9.1288Book Forum: MOOD DISORDERS
Book Forum: SCHIZOPHRENIA SPECTRUM
Book Forum: STRESS AND DISSOCIATION
Book Forum: MEMORY
Letter to the Editor
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