American Journal of Psychiatry
- Volume 156
- Number 7
- July 1999
Editorial
Images In Psychiatry
Special Article
Publication date: 01 July 1999
Pages990–999OBJECTIVE: The purpose of this study was to evaluate all available trial-based evidence on the effectiveness of clozapine in schizophrenia as compared with conventional neuroleptics. METHOD: All randomized, controlled trials comparing clozapine with a ...
https://doi.org/10.1176/ajp.156.7.990Regular Article
Publication date: 01 July 1999
Pages1000–1006OBJECTIVE: The recurrence of an affective disorder in people who initially recover from major depressive disorder was characterized by using the unique longitudinal prospective follow-up data from the National Institute of Mental Health Collaborative ...
https://doi.org/10.1176/ajp.156.7.1000Publication date: 01 July 1999
Pages1007–1013OBJECTIVE: The purpose of this study was to compare the acute outcomes of antidepressant medication and cognitive behavior therapy in the severely depressed outpatient subgroups of four major randomized trials. A secondary objective was to compare the ...
https://doi.org/10.1176/ajp.156.7.1007Publication date: 01 July 1999
Pages1014–1018OBJECTIVE: The authors’ goal was to determine the extent and pattern of blood serum monitoring of mood stabilizers in Medicaid patients with bipolar disorder. METHOD: Data were drawn from a Medicaid medical claims data set from Pittsburgh and the ...
https://doi.org/10.1176/ajp.156.7.1014Publication date: 01 July 1999
Pages1019–1023OBJECTIVE: New mood stabilizers are needed that possess efficacy for all phases of bipolar disorder. This study was designed to provide preliminary evidence for the safety and efficacy of a new anticonvulsant, lamotrigine, in adult patients with bipolar ...
https://doi.org/10.1176/ajp.156.7.1019Publication date: 01 July 1999
Pages1024–1028OBJECTIVE: This study compared the efficacy, tolerability, and safety of paroxetine and nortriptyline in depressed patients with ischemic heart disease. METHOD: After a 2-week, single-blind placebo lead-in phase, 81 outpatients with DSM-III-R-defined ...
https://doi.org/10.1176/ajp.156.7.1024Publication date: 01 July 1999
Pages1029–1034OBJECTIVE: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of ...
https://doi.org/10.1176/ajp.156.7.1029Publication date: 01 July 1999
Pages1035–1038OBJECTIVE: Because subjective memory complaints may indicate subtle functional brain abnormalities, the authors studied the influence of the major genetic risk for Alzheimer’s disease, the apolipoprotein E-4 (APOE-4) allele, on self-reports of memory ...
https://doi.org/10.1176/ajp.156.7.1035Publication date: 01 July 1999
Pages1039–1045OBJECTIVE: The literature reports considerable variation in the rates of psychiatric morbidity for patients with dementia with Lewy bodies. The authors intended to clarify the frequency of psychiatric morbidity in dementia with Lewy bodies and how it ...
https://doi.org/10.1176/ajp.156.7.1039Publication date: 01 July 1999
Pages1046–1051OBJECTIVE: The authors tested the hypothesis that the use of an atypical drug, clozapine, for patients with schizophrenia is related to less impairment in information processing deficits (assessed by prepulse inhibition of the startle response) than is ...
https://doi.org/10.1176/ajp.156.7.1046Publication date: 01 July 1999
Pages1052–1058OBJECTIVE: This study examined whether the electrophysiological correlates of language processing found previously to be abnormal in schizophrenia are also abnormal in schizotypal individuals. The authors used the N400 component to evaluate language ...
https://doi.org/10.1176/ajp.156.7.1052Publication date: 01 July 1999
Pages1059–1065OBJECTIVE: The aim of this study was to determine whether puberty plays a mediating role in onset of schizophrenia. The hypothesis was that there is an inverse relation between age at puberty (menarche) and age at onset in women. METHOD: Competent and ...
https://doi.org/10.1176/ajp.156.7.1059Publication date: 01 July 1999
Pages1065–1068OBJECTIVE: There has been an increasing focus on the ethical issues raised by studies requiring the withdrawal of effective medication in schizophrenic adults. This article examines the risks and benefits of a medication-free period for pediatric patients ...
https://doi.org/10.1176/ajp.156.7.1065Publication date: 01 July 1999
Pages1069–1074OBJECTIVE: This clinical assessment was designed to identify middle and high school students in need of formal evaluation for posttraumatic response symptoms following the 1995 bombing of the Alfred P. Murrah Federal Building in Oklahoma City. METHOD: A ...
https://doi.org/10.1176/ajp.156.7.1069Publication date: 01 July 1999
Pages1075–1079OBJECTIVE: The goal of this study was to assess the occurrence of anniversary reactions in Gulf War veterans 6 years after the conclusion of the war. METHOD: Subjects were administered questionnaires and asked to identify specific months of best and worst ...
https://doi.org/10.1176/ajp.156.7.1075Publication date: 01 July 1999
Pages1080–1085OBJECTIVE: The psychological defense styles of women who reported childhood sexual abuse were assessed and compared to those of women without childhood sexual abuse. METHOD: Subjects in a random community sample (N=354) of New Zealand women were ...
https://doi.org/10.1176/ajp.156.7.1080Clinical Case Conference
Brief Report
Publication date: 01 July 1999
Pages1091–1093OBJECTIVE: Gray matter volume and glucose utilization have been reported to be reduced in the left subgenual cingulate of subjects with familial bipolar or unipolar depression. It is unclear whether these findings are secondary to recurrent illness or are ...
https://doi.org/10.1176/ajp.156.7.1091Publication date: 01 July 1999
Pages1094–1096OBJECTIVE: The authors’ goal was to investigate the awareness of illness and subjective cognitive complaints of patients with either bipolar I disorder or bipolar II disorder during a phase of clinical stabilization. METHOD: They used a structured ...
https://doi.org/10.1176/ajp.156.7.1094Publication date: 01 July 1999
Pages1097–1099OBJECTIVE: The purpose of this study was to determine whether lack of awareness of motor dysfunction and lack of insight into mental dysfunction are related and to evaluate the longitudinal stability of lack of awareness of abnormal movements in ...
https://doi.org/10.1176/ajp.156.7.1097Publication date: 01 July 1999
Pages1100–1102OBJECTIVE: The authors’ goal was to determine whether there is an association between prenatal exposure to poliovirus infection and later development of schizophrenia. METHOD: All Finnish patients born between 1951 and 1969 with discharge diagnoses of ...
https://doi.org/10.1176/ajp.156.7.1100Publication date: 01 July 1999
Pages1103–1104OBJECTIVE: The involvement of heat shock proteins has been determined in the pathophysiology of several disorders of the central nervous system, including multiple sclerosis. To elucidate their role in schizophrenia, the authors investigated antibody ...
https://doi.org/10.1176/ajp.156.7.1103Publication date: 01 July 1999
Pages1105–1107OBJECTIVE: Recent evidence suggests that the cerebellum may play a role in higher cognitive functions and, therefore, may play an important role in schizophrenia. METHOD: The authors used magnetic resonance imaging to measure cerebellum and vermis volume ...
https://doi.org/10.1176/ajp.156.7.1105Book Forum: CLINICAL TOPICS
Book Forum: PSYCHOANALYTIC TOPICS
Book Forum: TRAUMA AND MEMORY
Book Forum: TEXTBOOKS
Letter to the Editor
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