American Journal of Psychiatry
- Volume 158
- Number 6
- June 2001
Editorial
Reviews and Overviews
Publication date: 01 June 2001
Pages839–847OBJECTIVE: Until now, prospective studies of aging have begun with 50–60-year-olds, not adolescents. Premature death, childhood variables, and alcohol abuse have been often ignored, as has successful aging. METHOD: The authors reviewed the existing ...
https://doi.org/10.1176/appi.ajp.158.6.839Publication date: 01 June 2001
Pages848–856OBJECTIVE: The authors developed a methodological basis for investigating how risk factors work together. Better methods are needed for understanding the etiology of disorders, such as psychiatric syndromes, that presumably are the result of complex ...
https://doi.org/10.1176/appi.ajp.158.6.848Publication date: 01 June 2001
Pages857–864OBJECTIVE: The authors reviewed the evidence for the claim that the Chinese tend to deny depression or express it somatically, examined the possible determinants of those characteristics, and explored implications of the findings for the diagnosis and ...
https://doi.org/10.1176/appi.ajp.158.6.857Images in Neuroscience
Clinical Case Conference
Images in Psychiatry
Article
Publication date: 01 June 2001
Pages872–877OBJECTIVE: The study examined the usefulness and clinical correlates of specific diagnostic criteria for apathy in Alzheimer’s disease. Whereas apathy is a frequent behavioral change in patients with Alzheimer’s disease, the lack of standardized ...
https://doi.org/10.1176/appi.ajp.158.6.872Publication date: 01 June 2001
Pages878–884OBJECTIVE: This study examined whether evidence of cerebrovascular disease in the form of magnetic resonance imaging (MRI) signal hyperintensities in white matter was associated with depressive symptoms in a high-functioning group of normal elderly ...
https://doi.org/10.1176/appi.ajp.158.6.878Publication date: 01 June 2001
Pages885–891OBJECTIVE: Stressful life events, long-term difficulties, and high neuroticism are established risk factors for depression. Less is known about their role in late-life depression, how they modify or mediate one another’s effects, and whether this differs ...
https://doi.org/10.1176/appi.ajp.158.6.885Publication date: 01 June 2001
Pages892–898OBJECTIVE: While benzodiazepine treatment is known to increase the risk of hip fracture in older populations, controversy persists over which characteristics of benzodiazepine use (e.g., elimination half-life, dosage, duration of use) are most associated ...
https://doi.org/10.1176/appi.ajp.158.6.892Publication date: 01 June 2001
Pages899–905OBJECTIVE: Depression is commonly associated with frontal hypometabolic activity accompanied by hypermetabolism in certain limbic regions. It is unclear whether successful antidepressant treatments reverse these abnormalities or create new resting levels ...
https://doi.org/10.1176/appi.ajp.158.6.899Publication date: 01 June 2001
Pages906–912OBJECTIVE: This study compared the efficacy and safety of paroxetine and imipramine with that of placebo in the treatment of bipolar depression in adult outpatients stabilized on a regimen of lithium. METHOD: In a double-blind, placebo-controlled study, ...
https://doi.org/10.1176/appi.ajp.158.6.906Publication date: 01 June 2001
Pages913–917OBJECTIVE: Puerperal psychosis, an episode of mania or psychosis precipitated by childbirth, follows approximately one in 1,000 deliveries. The evidence of clinical, outcome, and genetic studies supports the hypothesis that the majority of puerperal ...
https://doi.org/10.1176/appi.ajp.158.6.913Publication date: 01 June 2001
Pages918–925OBJECTIVE: Aberrant cholinergic inputs and synaptic neurotransmission in the prefrontal cortex induce cognitive impairment, which is a central feature of schizophrenia. Postsynaptic excitatory muscarinic cholinergic M1 and M4 receptors are the major ...
https://doi.org/10.1176/appi.ajp.158.6.918Publication date: 01 June 2001
Pages926–930OBJECTIVE: The authors’ goal was to test the hypothesis of extrastriatal D2 receptor selectivity as the mechanism of action of clozapine. METHOD: Positron emission tomography (PET) was used to examine extrastriatal as well as striatal dopamine D2 receptor ...
https://doi.org/10.1176/appi.ajp.158.6.926Publication date: 01 June 2001
Pages931–937OBJECTIVE: Clozapine has been found to be superior to typical neuroleptics in ameliorating the symptoms of refractory schizophrenia. This study evaluated clozapine’s effect on the rate of death due to suicide. METHOD: All patients over a 4-year period who ...
https://doi.org/10.1176/appi.ajp.158.6.931Publication date: 01 June 2001
Pages938–943OBJECTIVE: Previous research has noted functional and structural temporal lobe abnormalities in schizophrenia that relate to symptoms such as auditory hallucinations and thought disorder. The goal of the study was to determine whether the functional ...
https://doi.org/10.1176/appi.ajp.158.6.938Publication date: 01 June 2001
Pages944–948OBJECTIVE: Schizophrenia impairs performance on explicit, but not implicit, memory tasks, indicating that conscious awareness at retrieval is a critical determinant of impaired memory. The authors investigated implicit learning, i.e., knowledge ...
https://doi.org/10.1176/appi.ajp.158.6.944Brief Report
Publication date: 01 June 2001
Pages949–951OBJECTIVE: The authors’ goal was to determine what effect dyslipidemia has on clozapine’s plasma distribution. METHOD: [3H]Clozapine plus cold clozapine (335 ng/ml) were incubated in plasma samples with varying total cholesterol, lipoprotein cholesterol, ...
https://doi.org/10.1176/appi.ajp.158.6.949Publication date: 01 June 2001
Pages952–954OBJECTIVE: Previous imaging studies have described focal cortical changes in schizophrenia, with predominant findings of abnormalities in the temporal and frontal regions. The current study hypothesized that cerebellar regions involved in feedback and ...
https://doi.org/10.1176/appi.ajp.158.6.952Publication date: 01 June 2001
Pages955–958OBJECTIVE: Repeated functional magnetic resonance imaging (fMRI) studies of schizophrenic subjects may identify brain activity changes in response to interventions. To interpret the findings, however, it is crucial to know the test-retest reliability of ...
https://doi.org/10.1176/appi.ajp.158.6.955Publication date: 01 June 2001
Pages958–960OBJECTIVE: Most phosphorus-31 magnetic resonance spectroscopy (31P-MRS) studies have described measures of lower membrane anabolism or greater catabolism in the frontal lobes of patients with schizophrenia. The purpose of the present study was to evaluate ...
https://doi.org/10.1176/appi.ajp.158.6.958Publication date: 01 June 2001
Pages960–962OBJECTIVE: Serious defects in social skills acquired during childhood may be associated with aggressive behavior in later life. The authors studied whether being an only child was associated with criminality in adulthood and, secondly, if parental factors ...
https://doi.org/10.1176/appi.ajp.158.6.960Letter to the Editor
Book Forum: Child Psychiatry
Book Forum: Religion and Ethics
Book Forum: History: Changes and Challenges
Book Forum: Social Issues
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