American Journal of Psychiatry

Objective:The authors systematically reviewed the management of treatment-refractory depression in older people (defined as age 55 or older). Method:The authors conducted an electronic database search and reviewed the 14 articles that fit predetermined ...

https://doi.org/10.1176/appi.ajp.2011.10081165

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Combining Medications to Enhance Depression Outcomes (CO-MED): Acute and Long-Term Outcomes of a Single-Blind Randomized Study

Publication date: 01 July 2011

Pages689–701

Objective:Two antidepressant medication combinations were compared with selective serotonin reuptake inhibitor monotherapy to determine whether either combination produced a higher remission rate in first-step acute-phase (12 weeks) and long-term (7 ...

https://doi.org/10.1176/appi.ajp.2011.10111645

Effectiveness of Switching From Antipsychotic Polypharmacy to Monotherapy

Publication date: 01 July 2011

Pages702–708

Objective:This randomized trial addressed the risks and benefits of staying on antipsychotic polypharmacy or switching to monotherapy. Method:Adult outpatients with schizophrenia taking two antipsychotics (127 participants across 19 sites) were randomly ...

https://doi.org/10.1176/appi.ajp.2011.10060908

Gabapentin Combined With Naltrexone for the Treatment of Alcohol Dependence

Publication date: 01 July 2011

Pages709–717

Objective:Naltrexone, an efficacious medication for alcohol dependence, does not work for everyone. Symptoms such as insomnia and mood instability that are most evident during early abstinence might respond better to a different pharmacotherapy. ...

https://doi.org/10.1176/appi.ajp.2011.10101436

Disruption in the Balance Between Goal-Directed Behavior and Habit Learning in Obsessive-Compulsive Disorder

Publication date: 01 July 2011

Pages718–726

Objective:Obsessive-compulsive disorder (OCD) is characterized by repetitive, ritualistic behaviors and thought patterns. Although patients with OCD report that these compulsive behaviors are unproductive and often senseless, they are unable to desist. ...

https://doi.org/10.1176/appi.ajp.2011.10071062

Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [¹¹C]ABP688 PET and Postmortem Study

Publication date: 01 July 2011

Pages727–734

Objective:Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been proposed as an attractive target for novel therapeutic approaches to ...

https://doi.org/10.1176/appi.ajp.2011.09111607

Association of Predeployment Gaze Bias for Emotion Stimuli With Later Symptoms of PTSD and Depression in Soldiers Deployed in Iraq

Publication date: 01 July 2011

Pages735–741

Objective:Biased processing of emotion stimuli is thought to confer vulnerability to psychopathology, but few longitudinal studies of this link have been conducted. The authors examined the relationship between predeployment gaze bias for emotion stimuli ...

https://doi.org/10.1176/appi.ajp.2011.10091309

A Prospective 2-Year Study of Emergency Department Patients With Early-Phase Primary Psychosis or Substance-Induced Psychosis

Publication date: 01 July 2011

Pages742–748

Objective:The authors examined treatment utilization and outcomes over 2 years among patients admitted to emergency departments with early-phase primary or substance-induced psychosis. The main hypothesis was that patients with substance-induced psychosis ...

https://doi.org/10.1176/appi.ajp.2011.10071051