American Journal of Psychiatry

Poststroke depression (PSD) has been recognized by psychiatrists for more than 100 years, but controlled systematic studies did not begin until the 1970s. Meta-analyses addressing almost all major clinical issues in the field have emerged because of the ...

https://doi.org/10.1176/appi.ajp.2015.15030363

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A Selective Review of Cerebral Abnormalities in Patients With First-Episode Schizophrenia Before and After Treatment

Publication date: 01 December 2015

Pages232–243

The question of whether there are significant changes in brain anatomy and function at illness onset and over the early course of schizophrenia is a crucial issue with broad implications for prognosis, patient care, and models of illness pathophysiology. ...

https://doi.org/10.1176/appi.ajp.2015.15050641

Articles

Outcomes One and Two Winters Following Cognitive-Behavioral Therapy or Light Therapy for Seasonal Affective Disorder

Publication date: 05 November 2015

Pages244–251

Objective:The central public health challenge for winter seasonal affective disorder (SAD) is recurrence prevention. Preliminary studies suggest better long-term outcomes following cognitive-behavioral therapy tailored for SAD (CBT-SAD) than light ...

https://doi.org/10.1176/appi.ajp.2015.15060773

Impact of Antipsychotic Review and Nonpharmacological Intervention on Antipsychotic Use, Neuropsychiatric Symptoms, and Mortality in People With Dementia Living in Nursing Homes: A Factorial Cluster-Randomized Controlled Trial by the Well-Being and Health for People With Dementia (WHELD) Program

Publication date: 20 November 2015

Pages252–262

Objective:This study evaluated the impact of antipsychotic review, social interaction, and exercise, in conjunction with person-centered care, on antipsychotic use, agitation, and depression in people with dementia living in nursing homes.Method:A cluster-...

https://doi.org/10.1176/appi.ajp.2015.15010130

Reproductive Safety of Second-Generation Antipsychotics: Current Data From the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics

Publication date: 06 October 2015

Pages263–270

Objective:Second-generation antipsychotics are used to treat a spectrum of psychiatric illnesses in reproductive-age women. The National Pregnancy Registry for Atypical Antipsychotics was established to determine the risk of major malformations among ...

https://doi.org/10.1176/appi.ajp.2015.15040506

Video

An 8-Week Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Cariprazine in Patients With Bipolar I Depression

Publication date: 06 November 2015

Pages271–281

Objective:The authors evaluated the efficacy, safety, and tolerability of cariprazine, an atypical antipsychotic candidate, in adult patients with acute bipolar I depression.Method:This was an 8-week multinational, multicenter, randomized, double-blind, ...

https://doi.org/10.1176/appi.ajp.2015.15020164

Neural Correlates of the Propensity for Retaliatory Behavior in Youths With Disruptive Behavior Disorders

Publication date: 06 October 2015

Pages282–290

Objective:Youths with disruptive behavior disorders (DBD) (conduct disorder and oppositional defiant disorder) have an elevated risk for maladaptive reactive aggression. Theory suggests that this is due to an elevated sensitivity of basic threat circuitry ...

https://doi.org/10.1176/appi.ajp.2015.15020250

Video

Medial Prefrontal Aberrations in Major Depressive Disorder Revealed by Cytoarchitectonically Informed Voxel-Based Morphometry

Publication date: 01 December 2015

Pages291–298

Objective:The heterogeneous human frontal pole has been identified as a node in the dysfunctional network of major depressive disorder. The contribution of the medial (socio-affective) versus lateral (cognitive) frontal pole to major depression ...

https://doi.org/10.1176/appi.ajp.2015.15030349