American Journal of Psychiatry
- Volume 173
- Number 5
- May 2016
Editorials
Introspection
Treatment in Psychiatry
Images in Psychiatry
Education in Psychiatry
Articles
Publication date: 15 January 2016
Pages465–472Objective: Pharmacological treatments for agitation and aggression in patients with Alzheimer’s disease have shown limited efficacy. The authors assessed the heterogeneity of response to citalopram in the Citalopram for Agitation in Alzheimer Disease (...
https://doi.org/10.1176/appi.ajp.2015.15050648Publication date: 01 April 2016
Pages473–480Objective: Citalopram has been shown to improve agitation in patients with Alzheimer’s disease. The authors evaluated whether other neuropsychiatric symptoms improve with citalopram treatment compared with placebo. Method: In this planned secondary analysis ...
https://doi.org/10.1176/appi.ajp.2016.15020248Publication date: 12 February 2016
Pages481–490Objective: Although the average depressed patient benefits moderately from cognitive-behavioral therapy (CBT) or pharmacotherapy, some experience divergent outcomes. The authors tested frequencies, predictors, and moderators of negative and unusually ...
https://doi.org/10.1176/appi.ajp.2015.15040492Publication date: 18 December 2015
Pages491–498Objective: Suicidal ideation and behavior currently have no quick-acting pharmacological treatments that are suitable for independent outpatient use. Suicidality is linked to mental pain, which is modulated by the separation distress system through ...
https://doi.org/10.1176/appi.ajp.2015.15040535Publication date: 12 February 2016
Pages499–508Objective: Major depressive disorder has been associated with dysregulation of the endogenous opioid system. The authors sought to determine whether opioid modulation achieved through administration of ALKS 5461, a combination of a μ- and κ-opioid partial ...
https://doi.org/10.1176/appi.ajp.2015.15070921Publication date: 07 December 2015
Pages509–516Objective: α7-Nicotinic receptors are involved in the final maturation of GABA inhibitory synapses before birth. Choline at levels found in the amniotic fluid is an agonist at α7-nicotinic receptors. The authors conducted a double-blind placebo-controlled ...
https://doi.org/10.1176/appi.ajp.2015.15091188Publication date: 22 January 2016
Pages517–526Objective: Disruption of executive function is present in many neuropsychiatric disorders. However, determining the specificity of executive dysfunction across these disorders is challenging given high comorbidity of conditions. Here the authors ...
https://doi.org/10.1176/appi.ajp.2015.15060725Publication date: 22 January 2016
Pages527–534Objective: The authors sought to compare GABA levels in treated and untreated patients with psychosis with levels in their unaffected siblings and healthy control subjects, and to assess the effects of antipsychotic medications on GABA levels. Method: GABA+ ...
https://doi.org/10.1176/appi.ajp.2015.15020190Letters to the Editor
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