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American Journal of Psychiatry

  • Volume 162
  • Number 8
  • August 2005

In This Issue

Editorial

Reviews and Overviews

Publication date: 01 August 2005

Pages1403–1413

OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering motivational strength and decreased ability to control the desire to obtain drugs. In this review the authors explore how advances in neurobiology are approaching an ...

https://doi.org/10.1176/appi.ajp.162.8.1403

Publication date: 01 August 2005

Pages1414–1422

If neurobiology is ultimately to contribute to the development of successful treatments for drug addiction, researchers must discover the molecular mechanisms by which drug-seeking behaviors are consolidated into compulsive use, the mechanisms that ...

https://doi.org/10.1176/appi.ajp.162.8.1414

Publication date: 01 August 2005

Pages1423–1431

Psychiatrists have gradually developed a list of medications that are effective in the treatment of addictive disorders. Although alcoholism has received the most attention, nicotine, heroin, and cocaine have all been shown to be influenced by heredity. ...

https://doi.org/10.1176/appi.ajp.162.8.1423

Publication date: 01 August 2005

Pages1432–1440

In 1989, the National Institute on Drug Abuse (NIDA) established its Medications Development Program. This program has concentrated on developing pharmacotherapies for opiate and cocaine dependence and, more recently, for methamphetamine and cannabis ...

https://doi.org/10.1176/appi.ajp.162.8.1432

Publication date: 01 August 2005

Pages1441–1451

The authors review recent advances in the pharmacotherapy and pharmacogenetics of nicotine dependence. Despite the negative health consequences of smoking, approximately 23% of adults in the United States are daily tobacco smokers and approximately 13% ...

https://doi.org/10.1176/appi.ajp.162.8.1441

Publication date: 01 August 2005

Pages1452–1460

The past three decades have been marked by tremendous progress in behavioral therapies for drug abuse and dependence, as well as advances in the conceptualization of approaches to development of behavioral therapies. Cognitive behavior therapy, ...

https://doi.org/10.1176/appi.ajp.162.8.1452

Publication date: 01 August 2005

Pages1461–1472

OBJECTIVE: The authors examined the separate and combined effects of methamphetamine dependence and HIV infection on brain morphology. METHOD: Morphometric measures obtained from magnetic resonance imaging of methamphetamine-dependent and/or HIV-positive ...

https://doi.org/10.1176/appi.ajp.162.8.1461

Publication date: 01 August 2005

Pages1473–1482

OBJECTIVE: Animals self-administer many of the drugs that humans abuse, including cocaine. This article describes studies using preclinical animal models to differentiate the influences of neurobiological predisposition from environmental modulation of ...

https://doi.org/10.1176/appi.ajp.162.8.1473

Publication date: 01 August 2005

Pages1483–1493

The high rate of co-occurrence of substance use disorders and other psychiatric disorders is well established. The population of people with co-occurring disorders is heterogeneous, and the prevalence of comorbidity differs by diagnostic group. One of the ...

https://doi.org/10.1176/appi.ajp.162.8.1483

Publication date: 01 August 2005

Pages1494–1502

The past 30 years of research on the epidemiology of drug use, drug use disorders, and related conditions, such as HIV, has provided major insight into these conditions. Drug use peaked in the late 1970s, decreased across the 1980s, increased in the 1990s,...

https://doi.org/10.1176/appi.ajp.162.8.1494

Images in Neuroscience

Introspections

Images in Psychiatry

Article

Publication date: 01 August 2005

Pages1507–1514

OBJECTIVE: Research on the effects of cannabis on the brain and behavior has been surprisingly scarce. In humans, laboratory studies document toxicity and psychoactive effects of cannabinoids. However, among substance abuse patients, only a few studies ...

https://doi.org/10.1176/appi.ajp.162.8.1507

Publication date: 01 August 2005

Pages1521–1526

OBJECTIVE: Screening of adults in primary care has been recommended to reduce alcohol misuse. This study determined the rates and predictors of alcohol screening, screening positive, follow-up evaluation, and subsequently diagnosed alcohol use disorder in ...

https://doi.org/10.1176/appi.ajp.162.8.1521

Brief Report

Publication date: 01 August 2005

Pages1527–1529

OBJECTIVE: Many schizophrenia patients remain undiagnosed and untreated for long periods of time. It has been suggested that untreated psychosis may have deleterious neurotoxic effects. However, studies examining the correlates of untreated initial ...

https://doi.org/10.1176/appi.ajp.162.8.1527

Publication date: 01 August 2005

Pages1530–1533

OBJECTIVE: The authors sought to expand previous findings of vermal abnormalities in bipolar disorder patients. METHOD: Magnetic resonance imaging (MRI) morphometry was used to quantify vermal subregion volumes in 18 subjects with first-episode bipolar ...

https://doi.org/10.1176/appi.ajp.162.8.1530

Publication date: 01 August 2005

Pages1533–1535

OBJECTIVE: Schizophrenia patients consistently demonstrate performance deficits on visual masking procedures. The present study examined whether attentional manipulation would improve subjects’ performance on visual masking. METHOD: A metacontrast task ...

https://doi.org/10.1176/appi.ajp.162.8.1533

Publication date: 01 August 2005

Pages1535–1538

OBJECTIVE: The authors’ goal was to compare the efficacy and tolerability of 6 months’ treatment with flexible-dose ziprasidone and olanzapine in patients with schizophrenia or schizoaffective disorder. METHOD: Brief Psychiatric Rating Scale (BPRS) scores ...

https://doi.org/10.1176/appi.ajp.162.8.1535

Publication date: 01 August 2005

Pages1539–1541

OBJECTIVE: Research suggests that the normal left-greater-than-right angular gyrus volume asymmetry is reversed in chronic schizophrenia. The authors examined whether angular gyrus volume and asymmetry were abnormal in patients with first-episode ...

https://doi.org/10.1176/appi.ajp.162.8.1539

Letter to the Editor

Book Forum: Childhood Resilience

Book Forum: Geriatric Psychiatry

Book Forum: Substance Abuse

Book Forum: Personality and Personality Disorders

Correction

APA Official Actions

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