American Journal of Psychiatry
- Volume 169
- Number 9
- September 2012
In This Issue
Perspectives
Editorials
Perspectives
Images in Psychiatry
Perspectives
Treatment in Psychiatry
Publication date: 01 September 2012
Pages900–906Neuropsychiatric symptoms such as agitation and delusions occur commonly in elderly patients with dementia and often cause significant distress. Data on treatment efficacy are strongest for atypical antipsychotics, but these agents must be used with great ...
https://doi.org/10.1176/appi.ajp.2012.12030342Perspectives
Reviews and Overviews
Publication date: 01 September 2012
Pages907–915Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation ...
https://doi.org/10.1176/appi.ajp.2012.11091347New Research
Articles
Publication date: 01 September 2012
Pages916–925Patients treated in dynamic psychotherapy for depressive, anxious, or personality disorders were assessed over the course of their 5-year therapy for their use of defense mechanisms. Patients generally progressed from immature defenses, such as acting out,...
https://doi.org/10.1176/appi.ajp.2012.11091403Publication date: 01 September 2012
Pages926–936ObjectiveNot everyone who takes drugs becomes addicted, but the likelihood of developing drug addiction is greater in people with a family history of drug or alcohol dependence. Relatively little is known about how genetic risk mediates the development of ...
https://doi.org/10.1176/appi.ajp.2012.11091421Publication date: 01 September 2012
Pages937–945Antidepressants often take several weeks to work, but depressed women who took the antidepressant escitalopram plus 5 g/day of creatine monohydrate, a supplement that increases cellular energy, had earlier and greater symptom decreases than women who took ...
https://doi.org/10.1176/appi.ajp.2012.12010009Publication date: 01 September 2012
Pages946–953A meta-analysis showed that 9–12 sessions of supportive help delivered in the home to family caregivers for dementia patients had a salutary effect for the patients' behavioral symptoms, such as screaming and aggression, similar in size to the effect of ...
https://doi.org/10.1176/appi.ajp.2012.11101529Publication date: 01 September 2012
Pages954–962ObjectiveThe trajectory of cognitive decline in patients with late-onset Alzheimer’s disease varies widely. Genetic variations in CLU, PICALM, and CR1 are associated with Alzheimer’s disease, but it is unknown whether they exert their effects by altering ...
https://doi.org/10.1176/appi.ajp.2012.11121815Publication date: 01 September 2012
Pages963–973ObjectiveThe authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs).MethodThe family sample ...
https://doi.org/10.1176/appi.ajp.2012.11091423Publication date: 01 September 2012
Pages974–981ObjectiveThe α7 nicotinic acetylcholine receptor (nAChR) is associated with cognitive and P50 auditory gating deficits in schizophrenia, and α7 nAChR agonists can potentially reverse these deficits. The authors examined multiple dosages of tropisetron, a ...
https://doi.org/10.1176/appi.ajp.2012.11081289Publication date: 01 September 2012
Pages982–990ObjectiveGenome-wide association has been reported between the NCAN gene and bipolar disorder. The aims of this study were to characterize the clinical symptomatology most strongly influenced by NCAN and to explore the behavioral phenotype of Ncan ...
https://doi.org/10.1176/appi.ajp.2012.11101585Communications and Updates
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Communications and Updates
Book Forum
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