American Journal of Psychiatry

This review brings together recent research from molecular, neural circuit, animal model, and human studies to help understand the neurodevelopmental mechanisms underlying social anxiety disorder. Social anxiety disorder is common and debilitating, and it ...

https://doi.org/10.1176/appi.ajp.2014.14040449

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Comparison of Low and Moderate Dosages of Extended-Release Quetiapine in Borderline Personality Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

Publication date: 01 November 2014

Pages1174–1182

Objective:The authors compared the efficacy and tolerability of low and moderate dosages of extended-release quetiapine in adults with borderline personality disorder.Method:Ninety-five participants with DSM-IV borderline personality disorder were ...

https://doi.org/10.1176/appi.ajp.2014.13101348

Long-Term Effectiveness of Supported Employment: 5-Year Follow-Up of a Randomized Controlled Trial

Publication date: 01 November 2014

Pages1183–1190

Objective:The individual placement and support model of supported employment has been shown to be more effective than other vocational approaches in improving competitive work over 1–2 years in persons with severe mental illness. The authors evaluated the ...

https://doi.org/10.1176/appi.ajp.2014.13070857

Enhanced Neurocognitive Functioning and Positive Temperament in Twins Discordant for Bipolar Disorder

Publication date: 01 November 2014

Pages1191–1198

Objective:Based on evidence linking creativity and bipolar disorder, a model has been proposed whereby factors influencing liability to bipolar disorder confer certain traits with positive effects on reproductive fitness. The authors tested this model by ...

https://doi.org/10.1176/appi.ajp.2014.13121683

Combination Treatment With Varenicline and Bupropion in an Adaptive Smoking Cessation Paradigm

Publication date: 01 November 2014

Pages1199–1205

Objective:The authors assessed the efficacy and safety of combination treatment with varenicline and sustained-release bupropion for smokers who, based on an assessment of initial smoking reduction prior to the quit date, were deemed unlikely to achieve ...

https://doi.org/10.1176/appi.ajp.2014.13050595

Familial Recurrence of Autism Spectrum Disorder: Evaluating Genetic and Environmental Contributions

Publication date: 01 November 2014

Pages1206–1213

Objective:This study was designed to examine the pattern of familial recurrence of autism spectrum disorder (ASD) in terms of genetic and environmental contributions related to timing of birth.Method:The authors linked California Department of ...

https://doi.org/10.1176/appi.ajp.2014.13101359

Association of Gene Variants of the Renin-Angiotensin System With Accelerated Hippocampal Volume Loss and Cognitive Decline in Old Age

Publication date: 01 November 2014

Pages1214–1221

Objective:Genetic factors confer risk for neuropsychiatric phenotypes, but the polygenic etiology of these phenotypes makes identification of genetic culprits challenging. An approach to this challenge is to examine the effects of genetic variation on ...

https://doi.org/10.1176/appi.ajp.2014.13111543