American Journal of Psychiatry

Objective: Suicide, a major cause of death worldwide, has distinct biological underpinnings. The authors review and synthesize the research literature on biomarkers of suicide, with the aim of using the findings of these studies to develop a coherent model ...

https://doi.org/10.1176/appi.ajp.2014.14020194

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An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline

Publication date: 01 December 2014

Pages1278–1286

Objective: Major depressive disorder has been linked with inflammatory processes, but it is unclear whether individual differences in levels of inflammatory biomarkers could help match patients to treatments that are most likely to be beneficial. The ...

https://doi.org/10.1176/appi.ajp.2014.14010094

Identification and Replication of a Combined Epigenetic and Genetic Biomarker Predicting Suicide and Suicidal Behaviors

Publication date: 01 December 2014

Pages1287–1296

Considerable research suggests that suicide involves effects of genes, the environment, and their interaction. Analysis of three independent data sets of post-mortem brains revealed signs of increased methylation in one particular gene, SKA2, a finding ...

https://doi.org/10.1176/appi.ajp.2014.14010008

Clinical Outcomes and Genome-Wide Association for a Brain Methylation Site in an Antidepressant Pharmacogenetics Study in Mexican Americans

Publication date: 01 December 2014

Pages1297–1309

Objective: The authors compared the effectiveness of fluoxetine and desipramine treatment in a prospective double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role of whole-exome functional gene variations in the ...

https://doi.org/10.1176/appi.ajp.2014.12091165

Neural and Cognitive Correlates of the Common and Specific Variance Across Externalizing Problems in Young Adolescence

Publication date: 01 December 2014

Pages1310–1319

Longitudinal and family-based research suggests that conduct disorder, substance misuse, and ADHD involve both unique forms of dysfunction as well as more specific dysfunctions unique to each condition. Using direct measures of brain function, this study ...

https://doi.org/10.1176/appi.ajp.2014.13111499

Glutamate Metabolism in Major Depressive Disorder

Publication date: 01 December 2014

Pages1320–1327

Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-...

https://doi.org/10.1176/appi.ajp.2014.14010067

Effects of Depression, Anxiety, Comorbidity, and Antidepressants on Resting-State Heart Rate and Its Variability: An ELSA-Brasil Cohort Baseline Study

Publication date: 01 December 2014

Pages1328–1334

Objective: Increases in resting-state heart rate and decreases in its variability are associated with substantial morbidity and mortality, yet contradictory findings have been reported for the effects of the mood and anxiety disorders and of ...

https://doi.org/10.1176/appi.ajp.2014.13121605