American Journal of Psychiatry

Sensory processing deficits, first investigated by Kraepelin and Bleuler as possible pathophysiological mechanisms in schizophrenia, are now being recharacterized in the context of our current understanding of the molecular and neurobiological brain ...

https://doi.org/10.1176/appi.ajp.2014.13121691

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A Randomized Trial of Collaborative Depression Care in Obstetrics and Gynecology Clinics: Socioeconomic Disadvantage and Treatment Response

Publication date: 01 January 2015

Pages32–40

Objective:The authors evaluated whether an obstetrics-gynecology clinic-based collaborative depression care intervention is differentially effective compared with usual care for socially disadvantaged women with either no health insurance or with public ...

https://doi.org/10.1176/appi.ajp.2014.14020258

Treatment-Resistant Bipolar Depression: A Randomized Controlled Trial of Electroconvulsive Therapy Versus Algorithm-Based Pharmacological Treatment

Publication date: 01 January 2015

Pages41–51

Objective:Electroconvulsive therapy (ECT) is regarded by many clinicians as the most effective treatment for treatment-resistant bipolar depression, but no randomized controlled trials have been conducted, to the authors’ knowledge. They compared efficacy ...

https://doi.org/10.1176/appi.ajp.2014.13111517

Electroconvulsive Therapy Augmentation in Clozapine-Resistant Schizophrenia: A Prospective, Randomized Study

Publication date: 01 January 2015

Pages52–58

Objective:Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine ...

https://doi.org/10.1176/appi.ajp.2014.13060787

Impact of Early Intervention on Psychopathology, Crime, and Well-Being at Age 25

Publication date: 01 January 2015

Pages59–70

Objective:This randomized controlled trial tested the efficacy of early intervention to prevent adult psychopathology and improve well-being in early-starting conduct-problem children.Method:Kindergarteners (N=9,594) in three cohorts (1991–1993) at 55 ...

https://doi.org/10.1176/appi.ajp.2014.13060786

The STRIDE Weight Loss and Lifestyle Intervention for Individuals Taking Antipsychotic Medications: A Randomized Trial

Publication date: 01 January 2015

Pages71–81

Objectives:The STRIDE study assessed whether a lifestyle intervention, tailored for individuals with serious mental illnesses, reduced weight and diabetes risk. The authors hypothesized that the STRIDE intervention would be more effective than usual care ...

https://doi.org/10.1176/appi.ajp.2014.14020173

Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD

Publication date: 01 January 2015

Pages82–93

Objective:Obsessive-compulsive disorder (OCD) and Tourette’s syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically ...

https://doi.org/10.1176/appi.ajp.2014.13101306