American Journal of Psychiatry
- Volume 173
- Number 1
- January 2016
Editorials
Introspection
Clinical Case Conference
Perspectives in Global Mental Health
Reviews and Overviews
Publication date: 04 September 2015
Pages18–26Objective: Prescription opioid abuse and dependence have escalated rapidly in the United States over the past 20 years, leading to high rates of overdose deaths and a dramatic increase in the number of people seeking treatment for opioid dependence. The ...
https://doi.org/10.1176/appi.ajp.2015.15020262Publication date: 28 August 2015
Pages27–33The widespread use of MRI has led to a wealth of structural and functional anatomical findings in patients with diverse psychiatric disorders that may represent insights into pathobiology. However, recent technical reports indicate that data from popular ...
https://doi.org/10.1176/appi.ajp.2015.15060753Articles
Publication date: 28 August 2015
Pages34–43Objective: Impulsivity and inattention related to attention deficit hyperactivity disorder (ADHD) may increase food intake and, consequently, weight gain. However, findings on the association between obesity/overweight and ADHD are mixed. The authors ...
https://doi.org/10.1176/appi.ajp.2015.15020266Publication date: 16 October 2015
Pages44–52Objective: The purpose of this study was to determine whether microglial activity, measured using translocator-protein positron emission tomography (PET) imaging, is increased in unmedicated persons presenting with subclinical symptoms indicating that they ...
https://doi.org/10.1176/appi.ajp.2015.14101358Publication date: 20 October 2015
Pages53–59Objective: Antipsychotic drugs target dopamine and serotonin receptors as well as Kv11.1 potassium channels encoded by KCNH2. Variable patient responses and a wide range of side effects, however, limit their efficacy. Slow metabolizer status and gene ...
https://doi.org/10.1176/appi.ajp.2015.14050653Publication date: 04 September 2015
Pages60–68Objective: Alternative splicing of ErbB4 transcripts is dysregulated in the dorsolateral prefrontal cortex in schizophrenia. ErbB4 regulates the activity of parvalbumin interneurons, and therefore dysregulated ErbB4 splicing could contribute to lower ...
https://doi.org/10.1176/appi.ajp.2015.15020150Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment
Publication date: 28 August 2015
Pages69–77Objective: Clinical response to antipsychotic drug treatment is highly variable, yet prognostic biomarkers are lacking. The authors recently demonstrated that successful antipsychotic drug treatment alters resting-state functional connectivity of the ...
https://doi.org/10.1176/appi.ajp.2015.14121571Publication date: 06 November 2015
Pages78–89Objective: In healthy individuals, autobiographical memory recall is biased toward positive and away from negative events, while the opposite is found in depressed individuals. This study examined amygdala activity during autobiographical memory recall as ...
https://doi.org/10.1176/appi.ajp.2015.15010119Letters to the Editor
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