American Journal of Psychiatry

Tremendous progress has been made in basic neuroscience in recent decades. One area that has been especially successful is research on how the brain detects and responds to threats. Such studies have demonstrated comparable patterns of brain-behavior ...

https://doi.org/10.1176/appi.ajp.2016.16030353

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Suicide Attempt as a Risk Factor for Completed Suicide: Even More Lethal Than We Knew

Publication date: 13 August 2016

Pages1094–1100

Objective: While suicide attempt history is considered to robustly predict completed suicide, previous studies have limited generalizability because of using convenience samples of specific methods/treatment settings, disregarding previous attempts, or ...

https://doi.org/10.1176/appi.ajp.2016.15070854

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Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study

Publication date: 15 July 2016

Pages1101–1109

Objective: The Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy of right unilateral ultrabrief pulse electroconvulsive therapy (ECT) combined with venlafaxine for the treatment of geriatric depression. Method: PRIDE was a two-...

https://doi.org/10.1176/appi.ajp.2016.15081101

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A Novel Strategy for Continuation ECT in Geriatric Depression: Phase 2 of the PRIDE Study

Publication date: 15 July 2016

Pages1110–1118

Objective: The randomized phase (phase 2) of the Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy and tolerability of continuation ECT plus medication compared with medication alone in depressed geriatric patients after a ...

https://doi.org/10.1176/appi.ajp.2016.16010118

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Meta-Analysis of fMRI Studies of Disruptive Behavior Disorders

Publication date: 13 August 2016

Pages1119–1130

Objective: Functional magnetic resonance imaging (fMRI) studies in conduct disorder and in oppositional defiant disorder have shown inconsistencies. The aim of this meta-analysis of fMRI studies in disruptive behavior disorders was to establish the most ...

https://doi.org/10.1176/appi.ajp.2016.15081089

Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia

Publication date: 22 July 2016

Pages1131–1139

Objective: Deficient excitatory drive to parvalbumin-containing cortical interneurons is proposed as a key neural substrate for altered gamma oscillations and cognitive dysfunction in schizophrenia. However, a pathological entity producing such a deficit ...

https://doi.org/10.1176/appi.ajp.2016.16010025

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A Brief Clinical Tool to Estimate Individual Patients’ Risk of Depressive Relapse Following Remission: Proof of Concept

Publication date: 15 July 2016

Pages1140–1146

Objective: The authors sought to determine whether symptoms experienced by formerly depressed patients after at least 8 weeks of remission can be used to identify their risk for relapse during the next 6 months. Method: The study included 188 patients with ...

https://doi.org/10.1176/appi.ajp.2016.15111462