American Journal of Psychiatry
- Volume 174
- Number 2
- February 2017
Editorials
Clinical Case Conference
Images in Psychiatry
Reviews and Overviews
Publication date: 13 August 2016
Pages102–109The nosology for major psychiatric disorders developed by Emil Kraepelin in the 1890s has substantially shaped psychiatry. His theories, however, did not arise de novo, being strongly influenced by Karl Kahlbaum and Ewald Hecker. From the 1860–1880s, they ...
https://doi.org/10.1176/appi.ajp.2016.16030375Articles
Publication date: 15 September 2016
Pages110–117Objective: Deficits in reinforcement-based decision making have been reported in generalized anxiety disorder. However, the pathophysiology of these deficits is largely unknown; published studies have mainly examined adolescents, and the integrity of core ...
https://doi.org/10.1176/appi.ajp.2016.15111410Publication date: 09 September 2016
Pages118–124Objective: Neuroinflammation and abnormal immune responses are increasingly implicated in the pathophysiology of schizophrenia. Previous positron emission tomography (PET) studies targeting the translocator protein 18 kDa (TSPO) have been limited by high ...
https://doi.org/10.1176/appi.ajp.2016.16020171Publication date: 31 October 2016
Pages125–134Objective: Heightened generalization of fear from an aversively reinforced conditioned stimulus (CS+, a conditioned danger cue) to resembling stimuli is widely accepted as a pathogenic marker of posttraumatic stress disorder (PTSD). Indeed, a distress ...
https://doi.org/10.1176/appi.ajp.2016.15121549Publication date: 09 September 2016
Pages135–142Objective: Causes of placebo effects in antidepressant trials have been inferred from observational studies and meta-analyses, but their mechanisms have not been directly established. The goal of this study was to examine in a prospective, randomized ...
https://doi.org/10.1176/appi.ajp.2016.16020225Publication date: 24 October 2016
Pages143–153Objective: Few studies have characterized the epidemiology of first-episode psychoses in rural or urban settings since the introduction of early intervention psychosis services. To address this, the authors conducted a naturalistic cohort study in England, ...
https://doi.org/10.1176/appi.ajp.2016.16010103Publication date: 09 September 2016
Pages154–162Objective: The purpose of this article was to determine whether longitudinal historical data, commonly available in electronic health record (EHR) systems, can be used to predict patients’ future risk of suicidal behavior. Method: Bayesian models were ...
https://doi.org/10.1176/appi.ajp.2016.16010077Publication date: 13 August 2016
Pages163–171Objective: Lower dendritic spine density on layer 3 pyramidal cells in the dorsolateral prefrontal cortex (DLPFC) appears to contribute to cognitive dysfunction in schizophrenia, whereas psychosis is associated with excessive dopamine release in the ...
https://doi.org/10.1176/appi.ajp.2016.16020204Publication date: 19 August 2016
Pages172–185Objective: Underage drinking is widely recognized as a leading public health and social problem for adolescents in the United States. Being able to identify at-risk adolescents before they initiate heavy alcohol use could have important clinical and public ...
https://doi.org/10.1176/appi.ajp.2016.15121587Letters to the Editor
Book Forum
Editor's Note
Correction
Past Issues
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