American Journal of Psychiatry
- Volume 167
- Number 11
- November 2010
In This Issue
Perspectives
Editorials
Perspectives
Clinical Case Conference
Perspectives
Images in Psychiatry
Perspectives
Reviews and Overviews
Publication date: 01 November 2010
Pages1305–1320Major depressive disorder is a heritable psychiatric syndrome that appears to be associated with subtle cellular and molecular alterations in a complex neural network. The affected brain regions display dynamic neuroplastic adaptations to endocrine and ...
https://doi.org/10.1176/appi.ajp.2009.10030434New Research
Articles
Publication date: 01 November 2010
Pages1321–1330Objective: Clinicians, advocates, and policy makers have presented mental illnesses as medical diseases in efforts to overcome low service use, poor adherence rates, and stigma. The authors examined the impact of this approach with a 10-year comparison of ...
https://doi.org/10.1176/appi.ajp.2010.09121743Publication date: 01 November 2010
Pages1331–1338Objective: It is generally accepted that children of parents with schizophrenia or other forms of psychosis are at heightened risk for a range of behavioral problems. However, it remains unclear whether offspring of parents with different forms of ...
https://doi.org/10.1176/appi.ajp.2010.09020241Publication date: 01 November 2010
Pages1339–1348Objective: Slow waves and sleep spindles are the two main oscillations occurring during non-REM sleep. While slow oscillations are primarily generated and modulated by the cortex, sleep spindles are initiated by the thalamic reticular nucleus and regulated ...
https://doi.org/10.1176/appi.ajp.2010.09121731Publication date: 01 November 2010
Pages1349–1356Objective: Although the symptoms of autism exhibit quantitative distributions in nature, estimates of recurrence risk in families have never previously considered or incorporated quantitative characterization of the autistic phenotype among siblings. ...
https://doi.org/10.1176/appi.ajp.2010.09101470Publication date: 01 November 2010
Pages1357–1363Objective: Autism spectrum disorders are considered to be among the most heritable mental disorders, a notion based on surprisingly sparse data from small clinical studies. Population-based studies of the heritability of other neuropsychiatric disorders ...
https://doi.org/10.1176/appi.ajp.2010.10020223Publication date: 01 November 2010
Pages1364–1372Objective: Recent genome-wide analysis identified a genetic variant on 5p14.1 (rs4307059), which is associated with risk for autism spectrum disorder. This study investigated whether rs4307059 also operates as a quantitative trait locus underlying a ...
https://doi.org/10.1176/appi.ajp.2010.09121789Publication date: 01 November 2010
Pages1373–1380Objective: Postpartum major depression is a significant public health problem that strikes 15% of new mothers and confers adverse consequences for mothers, children, and families. The neural mechanisms involved in postpartum depression remain unknown, but ...
https://doi.org/10.1176/appi.ajp.2010.09081235Publication date: 01 November 2010
Pages1381–1390Objective: Suicide is a major social and public health problem, but its neurobiology in major depressive disorder is poorly understood. The purpose of this study was to use magnetic resonance diffusion tensor imaging to characterize abnormalities of white ...
https://doi.org/10.1176/appi.ajp.2010.09101513Publication date: 01 November 2010
Pages1391–1398Objective: The purpose of this study was to determine whether problem-solving therapy is an effective treatment in older patients with depression and executive dysfunction, a population likely to be resistant to antidepressant drugs. Method: Participants ...
https://doi.org/10.1176/appi.ajp.2010.09091327Publication date: 01 November 2010
Pages1399–1406Objective: Structural brain changes appear years before the onset of Alzheimer's disease, the leading cause of dementia late in life. Determining risk factors for such presymptomatic brain changes may assist in identifying candidates for future prevention ...
https://doi.org/10.1176/appi.ajp.2010.09111575Communications and Updates
Letters to the Editor
Communications and Updates
Book Forum
Communications and Updates
Books Received
Communications and Updates
Corrections
Past Issues
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