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American Journal of Psychiatry

  • Volume 167
  • Number 11
  • November 2010

In This Issue

Perspectives

Editorials

Perspectives

Clinical Case Conference

Perspectives

Images in Psychiatry

Perspectives

Reviews and Overviews

Publication date: 01 November 2010

Pages1305–1320

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated with subtle cellular and molecular alterations in a complex neural network. The affected brain regions display dynamic neuroplastic adaptations to endocrine and ...

https://doi.org/10.1176/appi.ajp.2009.10030434

New Research

Articles

Publication date: 01 November 2010

Pages1321–1330

Objective: Clinicians, advocates, and policy makers have presented mental illnesses as medical diseases in efforts to overcome low service use, poor adherence rates, and stigma. The authors examined the impact of this approach with a 10-year comparison of ...

https://doi.org/10.1176/appi.ajp.2010.09121743

Publication date: 01 November 2010

Pages1331–1338

Objective: It is generally accepted that children of parents with schizophrenia or other forms of psychosis are at heightened risk for a range of behavioral problems. However, it remains unclear whether offspring of parents with different forms of ...

https://doi.org/10.1176/appi.ajp.2010.09020241

Publication date: 01 November 2010

Pages1339–1348

Objective: Slow waves and sleep spindles are the two main oscillations occurring during non-REM sleep. While slow oscillations are primarily generated and modulated by the cortex, sleep spindles are initiated by the thalamic reticular nucleus and regulated ...

https://doi.org/10.1176/appi.ajp.2010.09121731

Publication date: 01 November 2010

Pages1349–1356

Objective: Although the symptoms of autism exhibit quantitative distributions in nature, estimates of recurrence risk in families have never previously considered or incorporated quantitative characterization of the autistic phenotype among siblings. ...

https://doi.org/10.1176/appi.ajp.2010.09101470

Publication date: 01 November 2010

Pages1357–1363

Objective: Autism spectrum disorders are considered to be among the most heritable mental disorders, a notion based on surprisingly sparse data from small clinical studies. Population-based studies of the heritability of other neuropsychiatric disorders ...

https://doi.org/10.1176/appi.ajp.2010.10020223

Publication date: 01 November 2010

Pages1364–1372

Objective: Recent genome-wide analysis identified a genetic variant on 5p14.1 (rs4307059), which is associated with risk for autism spectrum disorder. This study investigated whether rs4307059 also operates as a quantitative trait locus underlying a ...

https://doi.org/10.1176/appi.ajp.2010.09121789

Publication date: 01 November 2010

Pages1373–1380

Objective: Postpartum major depression is a significant public health problem that strikes 15% of new mothers and confers adverse consequences for mothers, children, and families. The neural mechanisms involved in postpartum depression remain unknown, but ...

https://doi.org/10.1176/appi.ajp.2010.09081235

Publication date: 01 November 2010

Pages1381–1390

Objective: Suicide is a major social and public health problem, but its neurobiology in major depressive disorder is poorly understood. The purpose of this study was to use magnetic resonance diffusion tensor imaging to characterize abnormalities of white ...

https://doi.org/10.1176/appi.ajp.2010.09101513

Publication date: 01 November 2010

Pages1391–1398

Objective: The purpose of this study was to determine whether problem-solving therapy is an effective treatment in older patients with depression and executive dysfunction, a population likely to be resistant to antidepressant drugs. Method: Participants ...

https://doi.org/10.1176/appi.ajp.2010.09091327

Publication date: 01 November 2010

Pages1399–1406

Objective: Structural brain changes appear years before the onset of Alzheimer's disease, the leading cause of dementia late in life. Determining risk factors for such presymptomatic brain changes may assist in identifying candidates for future prevention ...

https://doi.org/10.1176/appi.ajp.2010.09111575

Communications and Updates

Letters to the Editor

Communications and Updates

Book Forum

Communications and Updates

Books Received

Communications and Updates

Corrections

Past Issues

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