American Journal of Psychiatry

Ten years ago it was widely expected that the genetic basis of common disease would be resolved by genome-wide association studies (GWAS), large-scale studies in which the entire genome is covered by genetic markers. However, the bulk of heritable ...

https://doi.org/10.1176/appi.ajp.2010.10091340

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Relationship of Personality Disorders to the Course of Major Depressive Disorder in a Nationally Representative Sample

Publication date: 01 March 2011

Pages257–264

Objective:The purpose of this study was to examine the effects of specific personality disorder comorbidity on the course of major depressive disorder in a nationally representative sample. Method:Data were drawn from 1,996 participants in a national ...

https://doi.org/10.1176/appi.ajp.2010.10050695

Pharmacogenetic Approach at the Serotonin Transporter Gene as a Method of Reducing the Severity of Alcohol Drinking

Publication date: 01 March 2011

Pages265–275

Objective:Severe drinking can cause serious morbidity and death. Because the serotonin transporter (5-HTT) is an important regulator of neuronal 5-HT function, allelic differences at that gene may modulate the severity of alcohol consumption and predict ...

https://doi.org/10.1176/appi.ajp.2010.10050755

Prefrontal Cortical Deficits and Impaired Cognition-Emotion Interactions in Schizophrenia

Publication date: 01 March 2011

Pages276–285

Objective:Despite schizophrenia patients' reports of diminished experience of emotion in interviews and self-report measures, their emotional experience in the presence of emotional stimuli and in daily life (“in the moment”) appears largely intact. To ...

https://doi.org/10.1176/appi.ajp.2010.09081215

Risperidone Nonadherence and Return of Positive Symptoms in the Early Course of Schizophrenia

Publication date: 01 March 2011

Pages286–292

Objective:This study examined the effect of medication nonadherence on the return of positive symptoms among recent-onset schizophrenia patients. Method:Three sets of operational criteria for medication nonadherence with differing levels of severity were ...

https://doi.org/10.1176/appi.ajp.2010.09010087

Abnormal Modulation of Amygdala Activity in Schizophrenia in Response to Direct- and Averted-Gaze Threat-Related Facial Expressions

Publication date: 01 March 2011

Pages293–301

Objective:Reduced amygdala activation in individuals with schizophrenia is thought to contribute to impairments in emotion recognition and social functioning. Recent work, however, suggests that amygdala abnormalities in schizophrenia are more nuanced ...

https://doi.org/10.1176/appi.ajp.2010.10060832

Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications

Publication date: 01 March 2011

Pages302–316

Objective:To evaluate previously reported associations of copy number variants (CNVs) with schizophrenia and to identify additional associations, the authors analyzed CNVs in the Molecular Genetics of Schizophrenia study (MGS) and additional available ...

https://doi.org/10.1176/appi.ajp.2010.10060876

Overactive Error-Related Brain Activity as a Candidate Endophenotype for Obsessive-Compulsive Disorder: Evidence From Unaffected First-Degree Relatives

Publication date: 01 March 2011

Pages317–324

Objective:Hyperactivity in frontal-striatal circuits is assumed to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). In line with that, electrocortical correlates of overactive performance monitoring have been found to be ...

https://doi.org/10.1176/appi.ajp.2010.10030416