American Journal of Psychiatry

Objective:Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric disorder. In the present study, the authors investigated the presence of genomic convergence in the top findings of the five published genome-wide association ...

https://doi.org/10.1176/appi.ajp.2010.10070948

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Effectiveness of Mental Health Screening and Coordination of In-Theater Care Prior to Deployment to Iraq: A Cohort Study

Publication date: 01 April 2011

Pages378–385

Objective:The authors assessed the effectiveness of a systematic method of predeployment mental health screening to determine whether screening decreased negative outcomes during deployment in Iraq's combat setting. Method:Primary care providers performed ...

https://doi.org/10.1176/appi.ajp.2010.10091303

Longitudinal Follow-Up of Bipolar Disorder in Women With Premenstrual Exacerbation: Findings From STEP-BD

Publication date: 01 April 2011

Pages386–394

Objective:The impact of hormonal fluctuation during the menstrual cycle on the course of bipolar disorder is poorly understood. The authors determined the course of illness and time to relapse of bipolar disorder in prospectively followed women with ...

https://doi.org/10.1176/appi.ajp.2010.09121816

Effect of Nicotine Replacement Therapy on Agitation in Smokers With Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled Study

Publication date: 01 April 2011

Pages395–399

Objective:The authors conducted a randomized, placebo-controlled study of nicotine replacement therapy for the reduction of agitation and aggression in smokers with schizophrenia. Method:Participants were 40 smokers 18–65 years of age admitted to a ...

https://doi.org/10.1176/appi.ajp.2010.10040569

Evaluation of Functionally Meaningful Measures for Clinical Trials of Cognition Enhancement in Schizophrenia

Publication date: 01 April 2011

Pages400–407

Objective:Because reduction of psychotic symptoms in schizophrenia does not result in adequate community functioning, efforts have shifted to other areas, such as cognitive impairment. The U.S. Food and Drug Administration requires that drugs for ...

https://doi.org/10.1176/appi.ajp.2010.10030414

Maternally Derived Microduplications at 15q11-q13: Implication of Imprinted Genes in Psychotic Illness

Publication date: 01 April 2011

Pages408–417

Objective:Rare copy number variants have been implicated in different neurodevelopmental disorders, with the same copy number variants often increasing risk of more than one of these phenotypes. In a discovery sample of 22 schizophrenia patients with an ...

https://doi.org/10.1176/appi.ajp.2010.09111660

Correlation of Individual Differences in Schizotypal Personality Traits With Amphetamine-Induced Dopamine Release in Striatal and Extrastriatal Brain Regions

Publication date: 01 April 2011

Pages418–426

Objective:Schizotypal personality traits are associated with schizophrenia spectrum disorders, and individuals with schizophrenia spectrum disorders demonstrate increased dopamine transmission in the striatum. The authors sought to determine whether ...

https://doi.org/10.1176/appi.ajp.2010.10020165

Hippocampal Volume Development in Healthy Siblings of Childhood-Onset Schizophrenia Patients

Publication date: 01 April 2011

Pages427–435

Objective:Previous anatomic studies have established a reduction in hippocampal volume in schizophrenia, but few have investigated the progressive course of these changes and whether they are trait markers. In the present study, the authors examined ...

https://doi.org/10.1176/appi.ajp.2010.10050681