American Journal of Psychiatry

In recent years, increasing numbers of children have been diagnosed with bipolar disorder. In some cases, children with unstable mood clearly meet current diagnostic criteria for bipolar disorder, and in others, the diagnosis is unclear. Severe mood ...

https://doi.org/10.1176/appi.ajp.2010.10050766

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Cortical Development in Typically Developing Children With Symptoms of Hyperactivity and Impulsivity: Support for a Dimensional View of Attention Deficit Hyperactivity Disorder

Publication date: 01 February 2011

Pages143–151

Objective:There is considerable epidemiological and neuropsychological evidence that attention deficit hyperactivity disorder (ADHD) is best considered dimensionally, lying at the extreme end of a continuous distribution of symptoms and underlying ...

https://doi.org/10.1176/appi.ajp.2010.10030385

Disrupted Reinforcement Signaling in the Orbitofrontal Cortex and Caudate in Youths With Conduct Disorder or Oppositional Defiant Disorder and a High Level of Psychopathic Traits

Publication date: 01 February 2011

Pages152–162

Objective:Dysfunction in the amygdala and orbitofrontal cortex has been reported in youths and adults with psychopathic traits. The specific nature of the functional irregularities within these structures remains poorly understood. The authors used a ...

https://doi.org/10.1176/appi.ajp.2010.10010129

Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning

Publication date: 01 February 2011

Pages163–172

Objective:Despite increasing awareness of the many important roles played by brain-derived neurotrophic factor (BDNF) activation of TrkB, a fuller understanding of this system and the use of potential TrkB-acting therapeutic agents has been limited by the ...

https://doi.org/10.1176/appi.ajp.2010.10030326

Aberrant Brain Activation During a Working Memory Task in Psychotic Major Depression

Publication date: 01 February 2011

Pages173–182

Objective:The authors sought to better understand the neural circuitry associated with working memory deficits in psychotic major depression by examining brain function during an N-back task. Method:Study subjects were 16 patients with psychotic major ...

https://doi.org/10.1176/appi.ajp.2010.09121718

Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study

Publication date: 01 February 2011

Pages183–192

Objective:Alcoholism is associated with gray matter volume deficits in frontal and other brain regions. Whether persistent brain volume deficits in abstinence are predictive of subsequent time to alcohol relapse has not been established. The authors ...

https://doi.org/10.1176/appi.ajp.2010.10020233

Comparative Mortality Associated With Ziprasidone and Olanzapine in Real-World Use Among 18,154 Patients With Schizophrenia: The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC)

Publication date: 01 February 2011

Pages193–201

Objective:The authors compared 1-year mortality rates associated with ziprasidone and olanzapine in real-world use. Method:The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC) was an open-label, randomized, postmarketing large simple trial ...

https://doi.org/10.1176/appi.ajp.2010.08040484

Real-Time Electronic Ambulatory Monitoring of Substance Use and Symptom Expression in Schizophrenia

Publication date: 01 February 2011

Pages202–209

Objective:Despite evidence demonstrating elevated comorbidity between schizophrenia and substance use disorders, the underlying mechanisms of association remain poorly understood. The brief time intervals that characterize interactions between substance ...

https://doi.org/10.1176/appi.ajp.2010.10030463