American Journal of Psychiatry
- Volume 172
- Number 11
- November 2015
Editorials
Commentary
Introspections
Clinical Case Conference
Images in Psychiatry
Reviews and Overviews
Publication date: 11 September 2015
Pages1075–1091Depression and inflammation fuel one another. Inflammation plays a key role in depression’s pathogenesis for a subset of depressed individuals; depression also primes larger cytokine responses to stressors and pathogens that do not appear to habituate. ...
https://doi.org/10.1176/appi.ajp.2015.15020152Articles
Publication date: 05 June 2015
Pages1092–1100Objective: The purpose of this study was to clarify the causes of the smoking-schizophrenia association. Method: Using Cox proportional hazard and co-relative control models, the authors predicted future risk for a diagnosis of schizophrenia or nonaffective ...
https://doi.org/10.1176/appi.ajp.2015.15010126Publication date: 04 September 2015
Pages1101–1111Objective: Traumatic brain injury (TBI) is increasingly recognized as a risk factor for deleterious mental health and functional outcomes. The purpose of this study was to examine the strength and specificity of the association between deployment-acquired ...
https://doi.org/10.1176/appi.ajp.2015.14121572Publication date: 02 July 2015
Pages1112–1121Objective: Immune-related abnormalities are commonly reported in schizophrenia, including higher mRNA levels for the viral restriction factor interferon-induced transmembrane protein (IFITM) in the prefrontal cortex. The authors sought to clarify whether ...
https://doi.org/10.1176/appi.ajp.2015.15010019Publication date: 24 July 2015
Pages1122–1130Objective: CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), is involved in cognition through interneuron modulation of dopamine and glutamate signaling. CHRNA7 and its partially duplicated chimeric gene CHRFAM7A have been implicated in ...
https://doi.org/10.1176/appi.ajp.2015.14080978Publication date: 04 August 2015
Pages1131–1140Objective: Gene expression dysregulation in the brain has been associated with bipolar disorder through candidate gene and microarray expression studies, but questions remain about isoform-specific dysregulation and the role of noncoding RNAs whose ...
https://doi.org/10.1176/appi.ajp.2015.14101279Publication date: 17 July 2015
Pages1141–1147Objective: Diagnosis of schizophrenia is currently dependent on symptom-based criteria and lacks objective indicators. In this study, the authors investigated whether circulating miRNA can serve as a diagnostic biomarker for schizophrenia. Methods: Global ...
https://doi.org/10.1176/appi.ajp.2015.14030273Publication date: 02 July 2015
Pages1148–1159Objective: Postmortem studies in schizophrenia reveal alterations in gene products that regulate the release and extracellular persistence of GABA. However, results of in vivo studies of schizophrenia measuring total tissue GABA with magnetic resonance ...
https://doi.org/10.1176/appi.ajp.2015.14081031Letters to the Editor
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