American Journal of Psychiatry

Depression and inflammation fuel one another. Inflammation plays a key role in depression’s pathogenesis for a subset of depressed individuals; depression also primes larger cytokine responses to stressors and pathogens that do not appear to habituate. ...

https://doi.org/10.1176/appi.ajp.2015.15020152

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Smoking and Schizophrenia in Population Cohorts of Swedish Women and Men: A Prospective Co-Relative Control Study

Publication date: 05 June 2015

Pages1092–1100

Objective:The purpose of this study was to clarify the causes of the smoking-schizophrenia association.Method:Using Cox proportional hazard and co-relative control models, the authors predicted future risk for a diagnosis of schizophrenia or nonaffective ...

https://doi.org/10.1176/appi.ajp.2015.15010126

Prospective Longitudinal Evaluation of the Effect of Deployment-Acquired Traumatic Brain Injury on Posttraumatic Stress and Related Disorders: Results From the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

Publication date: 04 September 2015

Pages1101–1111

Objective:Traumatic brain injury (TBI) is increasingly recognized as a risk factor for deleterious mental health and functional outcomes. The purpose of this study was to examine the strength and specificity of the association between deployment-acquired ...

https://doi.org/10.1176/appi.ajp.2015.14121572

Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia

Publication date: 02 July 2015

Pages1112–1121

Objective:Immune-related abnormalities are commonly reported in schizophrenia, including higher mRNA levels for the viral restriction factor interferon-induced transmembrane protein (IFITM) in the prefrontal cortex. The authors sought to clarify whether ...

https://doi.org/10.1176/appi.ajp.2015.15010019

CHRNA7 and CHRFAM7A mRNAs: Co-Localized and Their Expression Levels Altered in the Postmortem Dorsolateral Prefrontal Cortex in Major Psychiatric Disorders

Publication date: 24 July 2015

Pages1122–1130

Objective:CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), is involved in cognition through interneuron modulation of dopamine and glutamate signaling. CHRNA7 and its partially duplicated chimeric gene CHRFAM7A have been implicated in ...

https://doi.org/10.1176/appi.ajp.2015.14080978

Transcriptome Sequencing of the Anterior Cingulate in Bipolar Disorder: Dysregulation of G Protein-Coupled Receptors

Publication date: 04 August 2015

Pages1131–1140

Objective:Gene expression dysregulation in the brain has been associated with bipolar disorder through candidate gene and microarray expression studies, but questions remain about isoform-specific dysregulation and the role of noncoding RNAs whose ...

https://doi.org/10.1176/appi.ajp.2015.14101279

Detection of Circulating miRNA Levels in Schizophrenia

Publication date: 17 July 2015

Pages1141–1147

Objective:Diagnosis of schizophrenia is currently dependent on symptom-based criteria and lacks objective indicators. In this study, the authors investigated whether circulating miRNA can serve as a diagnostic biomarker for schizophrenia.Methods:Global ...

https://doi.org/10.1176/appi.ajp.2015.14030273

In Vivo Measurement of GABA Transmission in Healthy Subjects and Schizophrenia Patients

Publication date: 02 July 2015

Pages1148–1159

Objective:Postmortem studies in schizophrenia reveal alterations in gene products that regulate the release and extracellular persistence of GABA. However, results of in vivo studies of schizophrenia measuring total tissue GABA with magnetic resonance ...

https://doi.org/10.1176/appi.ajp.2015.14081031