American Journal of Psychiatry

Cortico-limbic circuits provide a substrate for adaptive behavioral and emotional responses. However, dysfunction of these circuits can result in maladaptive responses that are associated with psychopathology. The prefrontal-limbic pathways are of ...

https://doi.org/10.1176/appi.ajp.2019.19101064

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Evidence for Dissociable Linkage of Dimensions of Psychopathology to Brain Structure in Youths

Publication date: 24 June 2019

Pages1000–1009

Objective:High comorbidity among psychiatric disorders suggests that they may share underlying neurobiological deficits. Abnormalities in cortical thickness and volume have been demonstrated in clinical samples of adults, but less is known when these ...

https://doi.org/10.1176/appi.ajp.2019.18070835

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Distinct Patterns of Neural Habituation and Generalization in Children and Adolescents With Autism With Low and High Sensory Overresponsivity

Publication date: 24 June 2019

Pages1010–1020

Objective:Sensory overresponsivity (SOR), an atypical negative reaction to sensory stimuli, is highly prevalent in autism spectrum disorder (ASD). Previous work has related SOR to increased brain response in sensory-limbic regions. This study investigated ...

https://doi.org/10.1176/appi.ajp.2019.18121333

Limbic Hyperactivity in Response to Emotionally Neutral Stimuli in Schizophrenia: A Neuroimaging Meta-Analysis of the Hypervigilant Mind

Publication date: 06 September 2019

Pages1021–1029

Objective:It has long been assumed that paranoid ideation may stem from an aberrant limbic response to threatening stimuli. However, results from functional neuroimaging studies using negative emotional stimuli have failed to confirm this assumption. One ...

https://doi.org/10.1176/appi.ajp.2019.19030247

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Hyperactivity and Reduced Activation of Anterior Hippocampus in Early Psychosis

Publication date: 18 October 2019

Pages1030–1038

Objective:In schizophrenia, the anterior hippocampus is hyperactive and shows reduced task-related recruitment, but the relationship between these two findings is unclear. The authors tested the hypothesis that hyperactivity impairs recruitment of the ...

https://doi.org/10.1176/appi.ajp.2019.19020151

No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

Publication date: 29 July 2019

Pages1039–1049

Objective:Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control ...

https://doi.org/10.1176/appi.ajp.2019.18101144