American Journal of Psychiatry
- Volume 165
- Number 8
- August 2008
In This Issue
Editorial
Commentary
Introspection
Treatment in Psychiatry
Clinical Case Conference
Images in Psychiatry
Reviews and Overviews
Publication date: 01 August 2008
Pages969–977Although the cognitive model of depression has evolved appreciably since its first formulation over 40 years ago, the potential interaction of genetic, neurochemical, and cognitive factors has only recently been demonstrated. Combining findings from ...
https://doi.org/10.1176/appi.ajp.2008.08050721Article
Publication date: 01 August 2008
Pages978–987Objective: This study evaluated the association of neurocognition and symptoms with measures of social and occupational functioning in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). Method: CATIE ...
https://doi.org/10.1176/appi.ajp.2008.07111713Publication date: 01 August 2008
Pages988–995Objective: Aripiprazole at clinically effective doses occupies some 90% of striatal dopamine 2 and 3 (D 2 /D 3 ) receptors. In order to further characterize its extrastriatal and time-dependent binding ...
https://doi.org/10.1176/appi.ajp.2008.07101574Publication date: 01 August 2008
Pages996–1005Objective: Transcranial magnetic stimulation (TMS) combined with high-density electroencephalography (EEG) can be used to directly examine the properties of thalamocortical circuits in the brain without engaging an individual in cognitive or ...
https://doi.org/10.1176/appi.ajp.2008.07111733Publication date: 01 August 2008
Pages1006–1014Objective: Although deficits in cognitive control are thought to contribute to the diverse cognitive and behavioral abnormalities in individuals with schizophrenia, the neural mechanisms underlying these deficits remain unclear. In this event-...
https://doi.org/10.1176/appi.ajp.2008.07060945Publication date: 01 August 2008
Pages1015–1023Objective: The authors sought to map gray matter changes in first-episode schizophrenia and to compare these with the changes in chronic schizophrenia. They postulated that the data would show a progression of changes from hippocampal deficits ...
https://doi.org/10.1176/appi.ajp.2008.07101562Publication date: 01 August 2008
Pages1024–1032Objective: Comparisons of diffusion tensor imaging (DTI) data between first-episode and chronic schizophrenia patients assessed in different studies have led to the suggestion that the decreased fractional anisotropy observed in chronic ...
https://doi.org/10.1176/appi.ajp.2008.07101640Publication date: 01 August 2008
Pages1033–1039Objective: There are significant unmet needs in the treatment of schizophrenia, especially for the treatment of cognitive impairment, negative syndrome, and cognitive function. Preclinical data suggest that agonists with selective affinity for ...
https://doi.org/10.1176/appi.ajp.2008.06091591Publication date: 01 August 2008
Pages1040–1047Objective: Nicotinic acetylcholine receptors are possible therapeutic targets for schizophrenia, as shown by neurobiological and molecular evidence for deficiencies in expression of α 7 -nicotinic receptors. Patients’ heavy ...
https://doi.org/10.1176/appi.ajp.2008.07071135Letters to the Editor
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