American Journal of Psychiatry

Genetic discoveries about human brain development and neuropsychiatric syndromes have changed the landscape of psychiatric research. The genotyping of hundreds of thousands of individuals has identified many hundreds of genomic regions that are associated ...

https://doi.org/10.1176/appi.ajp.2018.18111275

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Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis

Publication date: 05 November 2018

Pages21–28

Objective:Pharmacogenomic studies of antipsychotics have typically examined effects of individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome-wide association studies (GWAS) can quantify the influence of thousands of ...

https://doi.org/10.1176/appi.ajp.2018.17121363

Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia

Publication date: 05 November 2018

Pages29–35

Objective:Both rare copy number variants (CNVs) and common single-nucleotide polymorphisms (SNPs) contribute to liability to schizophrenia, but their etiological relationship has not been fully elucidated. The authors evaluated an additive model whereby ...

https://doi.org/10.1176/appi.ajp.2018.17040467

Developmental Contributions of Schizophrenia Risk Alleles and Childhood Peer Victimization to Early-Onset Mental Health Trajectories

Publication date: 29 November 2018

Pages36–43

Objective:Twin studies suggest that genetic factors contribute to continuity in mental health problems and that environmental factors are the major contributor to developmental change. The authors investigated the influence of psychiatric risk alleles on ...

https://doi.org/10.1176/appi.ajp.2018.18010075

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Electroencephalographic Biomarkers for Treatment Response Prediction in Major Depressive Illness: A Meta-Analysis

Publication date: 03 October 2018

Pages44–56

Objective:Reducing unsuccessful treatment trials could improve depression treatment. Quantitative EEG (QEEG) may predict treatment response and is being commercially marketed for this purpose. The authors sought to quantify the reliability of QEEG for ...

https://doi.org/10.1176/appi.ajp.2018.17121358

Multimodal Structural Neuroimaging Markers of Brain Development and ADHD Symptoms

Publication date: 17 September 2018

Pages57–66

Objective:Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with diverse associated risk factors and comorbidities. In this study, the authors sought to understand ADHD from a dimensional perspective and to identify ...

https://doi.org/10.1176/appi.ajp.2018.18010034

Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths

Publication date: 19 October 2018

Pages67–76

Objective:Childhood irritability is a common, impairing problem with changing age-related manifestations that predict long-term adverse outcomes. However, more investigation of overall and age-specific neural correlates is needed. Because youths with ...

https://doi.org/10.1176/appi.ajp.2018.18040491