American Journal of Psychiatry
- Volume 176
- Number 1
- January 2019
Editor’s Note
Editorials
Treatment in Psychiatry
Reviews and Overviews
Publication date: 01 January 2019
Pages12–20Genetic discoveries about human brain development and neuropsychiatric syndromes have changed the landscape of psychiatric research. The genotyping of hundreds of thousands of individuals has identified many hundreds of genomic regions that are associated ...
https://doi.org/10.1176/appi.ajp.2018.18111275Articles
Publication date: 05 November 2018
Pages21–28Objective: Pharmacogenomic studies of antipsychotics have typically examined effects of individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome-wide association studies (GWAS) can quantify the influence of thousands of ...
https://doi.org/10.1176/appi.ajp.2018.17121363Publication date: 05 November 2018
Pages29–35Objective: Both rare copy number variants (CNVs) and common single-nucleotide polymorphisms (SNPs) contribute to liability to schizophrenia, but their etiological relationship has not been fully elucidated. The authors evaluated an additive model whereby ...
https://doi.org/10.1176/appi.ajp.2018.17040467Publication date: 29 November 2018
Pages36–43Objective: Twin studies suggest that genetic factors contribute to continuity in mental health problems and that environmental factors are the major contributor to developmental change. The authors investigated the influence of psychiatric risk alleles on ...
https://doi.org/10.1176/appi.ajp.2018.18010075Publication date: 03 October 2018
Pages44–56Objective: Reducing unsuccessful treatment trials could improve depression treatment. Quantitative EEG (QEEG) may predict treatment response and is being commercially marketed for this purpose. The authors sought to quantify the reliability of QEEG for ...
https://doi.org/10.1176/appi.ajp.2018.17121358Publication date: 17 September 2018
Pages57–66Objective: Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with diverse associated risk factors and comorbidities. In this study, the authors sought to understand ADHD from a dimensional perspective and to identify ...
https://doi.org/10.1176/appi.ajp.2018.18010034Publication date: 19 October 2018
Pages67–76Objective: Childhood irritability is a common, impairing problem with changing age-related manifestations that predict long-term adverse outcomes. However, more investigation of overall and age-specific neural correlates is needed. Because youths with ...
https://doi.org/10.1176/appi.ajp.2018.18040491Letters to the Editor
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