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American Journal of Psychiatry

  • Volume 155
  • Number 6
  • June 1998

Editorial

Images in Neuroscience

Special Article

Publication date: 01 June 1998

Pages715–725

OBJECTIVE: This study was done to update and expand information given in recent reviews, provide a more systematic critique of past research, identify current research trends and issues, and explore possible strategies for future research in child ...

https://doi.org/10.1176/ajp.155.6.715

Regular Article

Publication date: 01 June 1998

Pages726–732

OBJECTIVE: Neurophysiological and pathological effects of ethanol may be mediated, to an important extent, via the glutamatergic system. Animal studies indicate the acute effects of ethanol disrupt glutamatergic neurotransmission by inhibiting the ...

https://doi.org/10.1176/ajp.155.6.726

Publication date: 01 June 1998

Pages733–740

OBJECTIVE: DSM-IV indicates that diagnoses of substance dependence should be further characterized with regard to the presence of a physiological component, defined by tolerance or withdrawal. This study evaluated the possible meaning of this distinction ...

https://doi.org/10.1176/ajp.155.6.733

Publication date: 01 June 1998

Pages751–760

OBJECTIVE: In a preliminary report, the authors observed that clozapine was superior to haloperidol in the treatment of positive and negative symptoms in stable outpatients with schizophrenia. In this final report, they examine the effects of clozapine on ...

https://doi.org/10.1176/ajp.155.6.751

Publication date: 01 June 1998

Pages761–767

OBJECTIVE: The authors previously observed an increase in striatal dopamine transmission following amphetamine challenge in 15 untreated patients with schizophrenia compared to 15 matched healthy subjects. The purpose of this study was to replicate this ...

https://doi.org/10.1176/ajp.155.6.761

Publication date: 01 June 1998

Pages768–773

OBJECTIVE: The authors investigated whether striatal dopamine D2 receptor binding characteristics in vivo are similar in men and women and whether there are sex-related differences in the decline in D2 receptor density due to aging. METHOD: Striatal D2 ...

https://doi.org/10.1176/ajp.155.6.768

Publication date: 01 June 1998

Pages774–778

OBJECTIVE: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients. METHOD: Magnetic resonance ...

https://doi.org/10.1176/ajp.155.6.774

Publication date: 01 June 1998

Pages779–784

OBJECTIVE: Diffuse brain atrophy is one of the gross pathological features of Alzheimer's disease and is a result of degenerative changes. The ε4 allele of apolipoprotein E (APOE) is a risk factor or susceptibility gene in late-onset sporadic Alzheimer's ...

https://doi.org/10.1176/ajp.155.6.779

Publication date: 01 June 1998

Pages785–794

OBJECTIVE: The authors examined the interaction of Alzheimer's disease severity and visual stimulus complexity in relation to regional brain function. METHOD: Each subject had five positron emission tomography [15]H2O scans while wearing goggles ...

https://doi.org/10.1176/ajp.155.6.785

Publication date: 01 June 1998

Pages795–799

OBJECTIVE: The goal of this study was to examine treatment outcome differences in relation to age at onset of first lifetime episode of recurrent major depression in elderly patients. METHOD: Patients were grouped as having early-onset (N=129) or late-...

https://doi.org/10.1176/ajp.155.6.795

Publication date: 01 June 1998

Pages800–805

OBJECTIVE: The aim of this study was to determine the rate of dissociative disorders among psychiatric inpatients in a university clinic in Turkey. METHOD: The Dissociative Experiences Scale was used to screen 166 consecutive inpatients admitted to the ...

https://doi.org/10.1176/ajp.155.6.800

Publication date: 01 June 1998

Pages806–811

OBJECTIVE: The aim of this study was to examine the relationship between childhood sexual abuse, childhood physical abuse, current psychiatric illness, and measures of dissociation in an adult population. METHOD: The authors used a randomly selected ...

https://doi.org/10.1176/ajp.155.6.806

Publication date: 01 June 1998

Pages812–817

OBJECTIVE: Exaggerated startle is a symptom of posttraumatic stress disorder (PTSD), but empirical studies have not consistently documented elevated baseline startle in PTSD. The authors proposed in a previous study that Vietnam veterans with PTSD exhibit ...

https://doi.org/10.1176/ajp.155.6.812

Publication date: 01 June 1998

Pages818–823

OBJECTIVE: The prevalence and etiology of pre- and postpartum depressive symptoms in women in a variety of family forms have been well documented, but relatively little research has been conducted on the adjustment of their male partners. The authors' ...

https://doi.org/10.1176/ajp.155.6.818

Publication date: 01 June 1998

Pages824–827

OBJECTIVE: Characteristics of patients receiving antidepressant therapy were examined to identify factors that may be associated with a medical-offset effect. METHOD: In a retrospective study, the authors analyzed claims data from a large health insurer ...

https://doi.org/10.1176/ajp.155.6.824

Images in Psychiatry

Brief Report

Publication date: 01 June 1998

Pages829–831

OBJECTIVE: The authors performed an analysis of their published chromosome 18 linkage data on 28 families in which there was bipolar disorder to test the potential of comorbid panic disorder to define a genetic subtype of bipolar disorder. METHOD: ...

https://doi.org/10.1176/ajp.155.6.829

Publication date: 01 June 1998

Pages835–837

OBJECTIVE: The authors previously reported a relationship between an allele encoding the low activity variant of catechol O-methyltransferase (COMT) and aggressive behavior in schizophrenic patients. This study replicates and extends these findings by ...

https://doi.org/10.1176/ajp.155.6.835

Publication date: 01 June 1998

Pages838–840

OBJECTIVE: The authors examined the effect of prolonged clozapine treatment on central serotonergic (5-HT) function in schizophrenia. METHOD: Prolactin responses to the 5-HT releasing agent d-fenfluramine were measured in two groups of 10 schizophrenic ...

https://doi.org/10.1176/ajp.155.6.838

Publication date: 01 June 1998

Pages841–843

OBJECTIVE: There is controversy regarding the long-lasting effects of the Holocaust on the adult children of Holocaust survivors. In the present study the authors examined the relationship between posttraumatic stress disorder (PTSD) characteristics of ...

https://doi.org/10.1176/ajp.155.6.841

Publication date: 01 June 1998

Pages844–845

OBJECTIVE: The aim of this study was to replicate reports of a high rate of dissociative identity disorder in psychiatric inpatients. METHOD: Subjects were 100 randomly selected women, 16–50 years old, who had recently been admitted to an acute ...

https://doi.org/10.1176/ajp.155.6.844

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Letters To The Editor

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