American Journal of Psychiatry
- Volume 155
- Number 6
- June 1998
Editorial
Images in Neuroscience
Special Article
Publication date: 01 June 1998
Pages715–725OBJECTIVE: This study was done to update and expand information given in recent reviews, provide a more systematic critique of past research, identify current research trends and issues, and explore possible strategies for future research in child ...
https://doi.org/10.1176/ajp.155.6.715Regular Article
Publication date: 01 June 1998
Pages726–732OBJECTIVE: Neurophysiological and pathological effects of ethanol may be mediated, to an important extent, via the glutamatergic system. Animal studies indicate the acute effects of ethanol disrupt glutamatergic neurotransmission by inhibiting the ...
https://doi.org/10.1176/ajp.155.6.726Publication date: 01 June 1998
Pages733–740OBJECTIVE: DSM-IV indicates that diagnoses of substance dependence should be further characterized with regard to the presence of a physiological component, defined by tolerance or withdrawal. This study evaluated the possible meaning of this distinction ...
https://doi.org/10.1176/ajp.155.6.733Publication date: 01 June 1998
Pages741–750OBJECTIVE: The goal of this study was to identify chromosomal regions likely to contain schizophrenia susceptibility genes. METHOD: A genomewide map of 310 microsatellite DNA markers with average spacing of 11 centimorgans was genotyped in 269 individuals—...
https://doi.org/10.1176/ajp.155.6.741Publication date: 01 June 1998
Pages751–760OBJECTIVE: In a preliminary report, the authors observed that clozapine was superior to haloperidol in the treatment of positive and negative symptoms in stable outpatients with schizophrenia. In this final report, they examine the effects of clozapine on ...
https://doi.org/10.1176/ajp.155.6.751Publication date: 01 June 1998
Pages761–767OBJECTIVE: The authors previously observed an increase in striatal dopamine transmission following amphetamine challenge in 15 untreated patients with schizophrenia compared to 15 matched healthy subjects. The purpose of this study was to replicate this ...
https://doi.org/10.1176/ajp.155.6.761Publication date: 01 June 1998
Pages768–773OBJECTIVE: The authors investigated whether striatal dopamine D2 receptor binding characteristics in vivo are similar in men and women and whether there are sex-related differences in the decline in D2 receptor density due to aging. METHOD: Striatal D2 ...
https://doi.org/10.1176/ajp.155.6.768Publication date: 01 June 1998
Pages774–778OBJECTIVE: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients. METHOD: Magnetic resonance ...
https://doi.org/10.1176/ajp.155.6.774Publication date: 01 June 1998
Pages779–784OBJECTIVE: Diffuse brain atrophy is one of the gross pathological features of Alzheimer's disease and is a result of degenerative changes. The ε4 allele of apolipoprotein E (APOE) is a risk factor or susceptibility gene in late-onset sporadic Alzheimer's ...
https://doi.org/10.1176/ajp.155.6.779Publication date: 01 June 1998
Pages785–794OBJECTIVE: The authors examined the interaction of Alzheimer's disease severity and visual stimulus complexity in relation to regional brain function. METHOD: Each subject had five positron emission tomography [15]H2O scans while wearing goggles ...
https://doi.org/10.1176/ajp.155.6.785Publication date: 01 June 1998
Pages795–799OBJECTIVE: The goal of this study was to examine treatment outcome differences in relation to age at onset of first lifetime episode of recurrent major depression in elderly patients. METHOD: Patients were grouped as having early-onset (N=129) or late-...
https://doi.org/10.1176/ajp.155.6.795Publication date: 01 June 1998
Pages800–805OBJECTIVE: The aim of this study was to determine the rate of dissociative disorders among psychiatric inpatients in a university clinic in Turkey. METHOD: The Dissociative Experiences Scale was used to screen 166 consecutive inpatients admitted to the ...
https://doi.org/10.1176/ajp.155.6.800Publication date: 01 June 1998
Pages806–811OBJECTIVE: The aim of this study was to examine the relationship between childhood sexual abuse, childhood physical abuse, current psychiatric illness, and measures of dissociation in an adult population. METHOD: The authors used a randomly selected ...
https://doi.org/10.1176/ajp.155.6.806Publication date: 01 June 1998
Pages812–817OBJECTIVE: Exaggerated startle is a symptom of posttraumatic stress disorder (PTSD), but empirical studies have not consistently documented elevated baseline startle in PTSD. The authors proposed in a previous study that Vietnam veterans with PTSD exhibit ...
https://doi.org/10.1176/ajp.155.6.812Publication date: 01 June 1998
Pages818–823OBJECTIVE: The prevalence and etiology of pre- and postpartum depressive symptoms in women in a variety of family forms have been well documented, but relatively little research has been conducted on the adjustment of their male partners. The authors' ...
https://doi.org/10.1176/ajp.155.6.818Publication date: 01 June 1998
Pages824–827OBJECTIVE: Characteristics of patients receiving antidepressant therapy were examined to identify factors that may be associated with a medical-offset effect. METHOD: In a retrospective study, the authors analyzed claims data from a large health insurer ...
https://doi.org/10.1176/ajp.155.6.824Images in Psychiatry
Brief Report
Publication date: 01 June 1998
Pages829–831OBJECTIVE: The authors performed an analysis of their published chromosome 18 linkage data on 28 families in which there was bipolar disorder to test the potential of comorbid panic disorder to define a genetic subtype of bipolar disorder. METHOD: ...
https://doi.org/10.1176/ajp.155.6.829Publication date: 01 June 1998
Pages832–834OBJECTIVE: The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies. METHOD: [123I]β-CIT and single photon emission computed tomography ...
https://doi.org/10.1176/ajp.155.6.832Publication date: 01 June 1998
Pages835–837OBJECTIVE: The authors previously reported a relationship between an allele encoding the low activity variant of catechol O-methyltransferase (COMT) and aggressive behavior in schizophrenic patients. This study replicates and extends these findings by ...
https://doi.org/10.1176/ajp.155.6.835Publication date: 01 June 1998
Pages838–840OBJECTIVE: The authors examined the effect of prolonged clozapine treatment on central serotonergic (5-HT) function in schizophrenia. METHOD: Prolactin responses to the 5-HT releasing agent d-fenfluramine were measured in two groups of 10 schizophrenic ...
https://doi.org/10.1176/ajp.155.6.838Publication date: 01 June 1998
Pages841–843OBJECTIVE: There is controversy regarding the long-lasting effects of the Holocaust on the adult children of Holocaust survivors. In the present study the authors examined the relationship between posttraumatic stress disorder (PTSD) characteristics of ...
https://doi.org/10.1176/ajp.155.6.841Publication date: 01 June 1998
Pages844–845OBJECTIVE: The aim of this study was to replicate reports of a high rate of dissociative identity disorder in psychiatric inpatients. METHOD: Subjects were 100 randomly selected women, 16–50 years old, who had recently been admitted to an acute ...
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