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American Journal of Psychiatry

  • Volume 159
  • Number 2
  • February 2002

Editorial

Reviews and Overviews

Publication date: 01 February 2002

Pages180–190

OBJECTIVE: The “atypical” profile of the new antipsychotics clozapine, olanzapine, quetiapine, and risperidone has been linked to combined antagonism of serotonin 2 (5-HT2) and dopamine 2 (D2) receptors. Although amisulpride is a highly selective D3/D2 ...

https://doi.org/10.1176/appi.ajp.159.2.180

Publication date: 01 February 2002

Pages191–200

OBJECTIVE: Antidepressant efficacy trials use multiple exclusion criteria that are intended primarily to maximize differences between the drug and placebo. These exclusion criteria were implemented prior to having undergone rigorous testing, however, and ...

https://doi.org/10.1176/appi.ajp.159.2.191

Publication date: 01 February 2002

Pages201–207

The ultimate goal of clinical intervention research is to find a way to improve the care and lives of people suffering from specific psychiatric symptoms, illnesses, and/or disabilities. This article provides to clinical researchers a set of issues to ...

https://doi.org/10.1176/appi.ajp.159.2.201

Images in Neuroscience

Clinical Case Conference

Images in Psychiatry

Article

Publication date: 01 February 2002

Pages217–226

OBJECTIVE: Despite evidence for hippocampal structural abnormalities in patients with schizophrenia, their functional correlates remain largely unknown. This study investigated the neuropsychological correlates of hippocampal volume in 43 men and 32 women ...

https://doi.org/10.1176/appi.ajp.159.2.217

Publication date: 01 February 2002

Pages227–237

OBJECTIVE: Positron emission tomography (PET) was used to compare cerebral metabolic patterns in schizophrenic subjects with predominantly negative symptoms (alogia, affective flattening, avolition, and attentional impairment) and in those with ...

https://doi.org/10.1176/appi.ajp.159.2.227

Publication date: 01 February 2002

Pages238–243

OBJECTIVE: The authors prospectively assessed the relationship between minor physical anomalies identified in childhood and adult psychiatric outcome. METHOD: In 1972, minor physical anomalies were measured in a group of 265 Danish children ages 11–13. ...

https://doi.org/10.1176/appi.ajp.159.2.238

Publication date: 01 February 2002

Pages244–250

OBJECTIVE: Schizophrenia is generally characterized by a progressive decline in functioning. Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not ...

https://doi.org/10.1176/appi.ajp.159.2.244

Publication date: 01 February 2002

Pages255–262

OBJECTIVE: The authors compared the efficacy and safety of three atypical antipsychotics (clozapine, olanzapine, and risperidone) with one another and with haloperidol in the treatment of patients with chronic schizophrenia or schizoaffective disorder. ...

https://doi.org/10.1176/appi.ajp.159.2.255

Publication date: 01 February 2002

Pages263–268

OBJECTIVE: Little is known about the longitudinal course of symptoms in adult patients with obsessive-compulsive disorder (OCD), although some evidence exists regarding symptom stability in children and adolescents. This study systematically investigated ...

https://doi.org/10.1176/appi.ajp.159.2.263

Publication date: 01 February 2002

Pages269–275

OBJECTIVE: Long-term outcome associated with cingulotomy for obsessive-compulsive disorder (OCD) was prospectively assessed. Findings are reported for 18 patients previously described in 1995 and for 26 new patients. METHOD: An open preoperative and ...

https://doi.org/10.1176/appi.ajp.159.2.269

Publication date: 01 February 2002

Pages291–296

OBJECTIVE: Gilles de la Tourette’s syndrome is a well-characterized disorder with clear DSM-IV criteria. However, the great deal of clinical variability across patients may represent an underlying etiologic complexity. Issues of phenotypic heterogeneity ...

https://doi.org/10.1176/appi.ajp.159.2.291

Publication date: 01 February 2002

Pages297–301

OBJECTIVE: Borrelia burgdorferi infection can affect the CNS and mimic psychiatric disorders. It is not known whether Borrelia burgdorferi contributes to overall psychiatric morbidity. The authors compared the prevalence of antibodies to Borrelia ...

https://doi.org/10.1176/appi.ajp.159.2.297

Brief Report

Publication date: 01 February 2002

Pages302–304

OBJECTIVE: Recognition of facial emotion was examined in manic subjects to explore whether aberrant interpersonal interactions are related to impaired perception of social cues. METHOD: Manic subjects with bipolar I disorder (N=8), euthymic subjects with ...

https://doi.org/10.1176/appi.ajp.159.2.302

Publication date: 01 February 2002

Pages304–306

OBJECTIVE: The authors’ goal was to determine whether patients with bipolar II disorder had altered regional brain responses to novel motor sequences. METHOD: Regional cerebral blood flow was measured with positron emission tomography in 13 patients with ...

https://doi.org/10.1176/appi.ajp.159.2.304

Publication date: 01 February 2002

Pages307–309

OBJECTIVE: The relationships of age at onset and childhood psychopathology to 2-year clinical and functional outcomes in first-admission patients with bipolar I disorder were examined. METHOD: Patients with bipolar I disorder (N=123) presenting with ...

https://doi.org/10.1176/appi.ajp.159.2.307

Publication date: 01 February 2002

Pages309–312

OBJECTIVE: The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striatal dopamine transporter levels, which may explain psychostimulant effects in this disorder. METHOD: Single photon emission computed ...

https://doi.org/10.1176/appi.ajp.159.2.309

Publication date: 01 February 2002

Pages312–314

OBJECTIVE: The authors describe obstacles to children’s disclosure of their sexual abuse experiences. METHOD: Ten children’s descriptions of 102 incidents of sexual abuse and the process of disclosing these incidents during police interviews were studied. ...

https://doi.org/10.1176/appi.ajp.159.2.312

Letter to the Editor

Book Forum: Textbooks

Book Forum: Intelligence and the Mind

Book Forum: Evolution, Genes, and the Mind

Book Forum: Soma and Psyche

Past Issues

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No.11
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1 Nov 2024

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No.10
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No.9
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Vol. 181 | No. 9

No.8
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1 Aug 2024

Vol. 181 | No. 8