American Journal of Psychiatry
- Volume 159
- Number 2
- February 2002
Editorial
Reviews and Overviews
Publication date: 01 February 2002
Pages180–190OBJECTIVE: The “atypical” profile of the new antipsychotics clozapine, olanzapine, quetiapine, and risperidone has been linked to combined antagonism of serotonin 2 (5-HT2) and dopamine 2 (D2) receptors. Although amisulpride is a highly selective D3/D2 ...
https://doi.org/10.1176/appi.ajp.159.2.180Publication date: 01 February 2002
Pages191–200OBJECTIVE: Antidepressant efficacy trials use multiple exclusion criteria that are intended primarily to maximize differences between the drug and placebo. These exclusion criteria were implemented prior to having undergone rigorous testing, however, and ...
https://doi.org/10.1176/appi.ajp.159.2.191Publication date: 01 February 2002
Pages201–207The ultimate goal of clinical intervention research is to find a way to improve the care and lives of people suffering from specific psychiatric symptoms, illnesses, and/or disabilities. This article provides to clinical researchers a set of issues to ...
https://doi.org/10.1176/appi.ajp.159.2.201Images in Neuroscience
Clinical Case Conference
Images in Psychiatry
Article
Publication date: 01 February 2002
Pages217–226OBJECTIVE: Despite evidence for hippocampal structural abnormalities in patients with schizophrenia, their functional correlates remain largely unknown. This study investigated the neuropsychological correlates of hippocampal volume in 43 men and 32 women ...
https://doi.org/10.1176/appi.ajp.159.2.217Publication date: 01 February 2002
Pages227–237OBJECTIVE: Positron emission tomography (PET) was used to compare cerebral metabolic patterns in schizophrenic subjects with predominantly negative symptoms (alogia, affective flattening, avolition, and attentional impairment) and in those with ...
https://doi.org/10.1176/appi.ajp.159.2.227Publication date: 01 February 2002
Pages238–243OBJECTIVE: The authors prospectively assessed the relationship between minor physical anomalies identified in childhood and adult psychiatric outcome. METHOD: In 1972, minor physical anomalies were measured in a group of 265 Danish children ages 11–13. ...
https://doi.org/10.1176/appi.ajp.159.2.238Publication date: 01 February 2002
Pages244–250OBJECTIVE: Schizophrenia is generally characterized by a progressive decline in functioning. Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not ...
https://doi.org/10.1176/appi.ajp.159.2.244Publication date: 01 February 2002
Pages251–254OBJECTIVE: The authors used single-subject functional imaging analyses to 1) corroborate the findings of anterior cingulate hypoperfusion during an attentional task in schizophrenia and 2) examine whether anterior cingulate activation is associated with ...
https://doi.org/10.1176/appi.ajp.159.2.251Publication date: 01 February 2002
Pages255–262OBJECTIVE: The authors compared the efficacy and safety of three atypical antipsychotics (clozapine, olanzapine, and risperidone) with one another and with haloperidol in the treatment of patients with chronic schizophrenia or schizoaffective disorder. ...
https://doi.org/10.1176/appi.ajp.159.2.255Publication date: 01 February 2002
Pages263–268OBJECTIVE: Little is known about the longitudinal course of symptoms in adult patients with obsessive-compulsive disorder (OCD), although some evidence exists regarding symptom stability in children and adolescents. This study systematically investigated ...
https://doi.org/10.1176/appi.ajp.159.2.263Publication date: 01 February 2002
Pages269–275OBJECTIVE: Long-term outcome associated with cingulotomy for obsessive-compulsive disorder (OCD) was prospectively assessed. Findings are reported for 18 patients previously described in 1995 and for 26 new patients. METHOD: An open preoperative and ...
https://doi.org/10.1176/appi.ajp.159.2.269Publication date: 01 February 2002
Pages276–283OBJECTIVE: The purpose of this study was to compare psychosocial functioning in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder and patients with major depressive disorder and no personality disorder. METHOD: ...
https://doi.org/10.1176/appi.ajp.159.2.276Publication date: 01 February 2002
Pages284–290OBJECTIVE: This study tested the factor structure of the DSM-IV criteria for borderline personality disorder by using confirmatory methods for the analysis of covariance structures in a large group from a multisite study. METHOD: A total of 668 primarily ...
https://doi.org/10.1176/appi.ajp.159.2.284Publication date: 01 February 2002
Pages291–296OBJECTIVE: Gilles de la Tourette’s syndrome is a well-characterized disorder with clear DSM-IV criteria. However, the great deal of clinical variability across patients may represent an underlying etiologic complexity. Issues of phenotypic heterogeneity ...
https://doi.org/10.1176/appi.ajp.159.2.291Publication date: 01 February 2002
Pages297–301OBJECTIVE: Borrelia burgdorferi infection can affect the CNS and mimic psychiatric disorders. It is not known whether Borrelia burgdorferi contributes to overall psychiatric morbidity. The authors compared the prevalence of antibodies to Borrelia ...
https://doi.org/10.1176/appi.ajp.159.2.297Brief Report
Publication date: 01 February 2002
Pages302–304OBJECTIVE: Recognition of facial emotion was examined in manic subjects to explore whether aberrant interpersonal interactions are related to impaired perception of social cues. METHOD: Manic subjects with bipolar I disorder (N=8), euthymic subjects with ...
https://doi.org/10.1176/appi.ajp.159.2.302Publication date: 01 February 2002
Pages304–306OBJECTIVE: The authors’ goal was to determine whether patients with bipolar II disorder had altered regional brain responses to novel motor sequences. METHOD: Regional cerebral blood flow was measured with positron emission tomography in 13 patients with ...
https://doi.org/10.1176/appi.ajp.159.2.304Publication date: 01 February 2002
Pages307–309OBJECTIVE: The relationships of age at onset and childhood psychopathology to 2-year clinical and functional outcomes in first-admission patients with bipolar I disorder were examined. METHOD: Patients with bipolar I disorder (N=123) presenting with ...
https://doi.org/10.1176/appi.ajp.159.2.307Publication date: 01 February 2002
Pages309–312OBJECTIVE: The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striatal dopamine transporter levels, which may explain psychostimulant effects in this disorder. METHOD: Single photon emission computed ...
https://doi.org/10.1176/appi.ajp.159.2.309Publication date: 01 February 2002
Pages312–314OBJECTIVE: The authors describe obstacles to children’s disclosure of their sexual abuse experiences. METHOD: Ten children’s descriptions of 102 incidents of sexual abuse and the process of disclosing these incidents during police interviews were studied. ...
https://doi.org/10.1176/appi.ajp.159.2.312Letter to the Editor
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