American Journal of Psychiatry
- Volume 157
- Number 7
- July 2000
Editorial
Reviews and Overviews
Publication date: 01 July 2000
Pages1041–1050OBJECTIVE: The authors assess implications of DSM criteria for schizophrenia by reviewing the criteria’s 1) emphasis on psychotic features, 2) dissociation of symptoms from their etiology, 3) exclusive reliance on clinical features but exclusion of ...
https://doi.org/10.1176/appi.ajp.157.7.1041Clinical Case Conference
Images in Psychiatry
Regular Article
Publication date: 01 July 2000
Pages1058–1064OBJECTIVE: Point mutations in mitochondrial DNA (mtDNA) are one mechanism that could explain the apparent excess maternal transmission of bipolar affective disorder observed in some families. The authors sequenced the mtDNA from probands with bipolar ...
https://doi.org/10.1176/appi.ajp.157.7.1058Publication date: 01 July 2000
Pages1065–1070OBJECTIVE: The authors estimated the prevalence of psychoses among the Hutterites in Manitoba, Canada, who lived in 102 communal farms or colonies. The study stemmed from an earlier epidemiological survey of North American Hutterite colonies (1950–1953), ...
https://doi.org/10.1176/appi.ajp.157.7.1065Publication date: 01 July 2000
Pages1071–1076OBJECTIVE: The deficit syndrome is a subtype of schizophrenia characterized by primary and enduring negative features of psychopathology. It appears to reflect a distinct subtype within the syndrome of schizophrenia. Little is known about the familial or ...
https://doi.org/10.1176/appi.ajp.157.7.1071Publication date: 01 July 2000
Pages1077–1083OBJECTIVE: Because attention deficit hyperactivity disorder (ADHD) is relatively infrequent among girls, little is known about the causes of ADHD in girls. To help fill this gap in the literature, the authors assessed the familial transmission of ADHD in ...
https://doi.org/10.1176/appi.ajp.157.7.1077Publication date: 01 July 2000
Pages1084–1088OBJECTIVE: Over 30,000 people a year commit suicide in the United States. Prior attempted suicide and hopelessness are the most powerful clinical predictors of future completed suicide. The authors hypothesized that “reasons for living” might protect or ...
https://doi.org/10.1176/appi.ajp.157.7.1084Publication date: 01 July 2000
Pages1089–1094OBJECTIVE: Prescriptions of antidepressant medications have increased significantly over the past 15 years across the life cycle. One overall correlate of medication use in older adults is race, with African Americans using fewer medications than whites. ...
https://doi.org/10.1176/appi.ajp.157.7.1089Publication date: 01 July 2000
Pages1095–1100OBJECTIVE: At least three studies have indicated that patients with psychotic major depression studied under non-drug-free conditions differ from patients with nonpsychotic major depression and healthy comparison subjects on several measures of ...
https://doi.org/10.1176/appi.ajp.157.7.1095Publication date: 01 July 2000
Pages1101–1107OBJECTIVE: The authors tested the hypothesis that a lifetime history of panic-agoraphobic spectrum symptoms predicts a poorer response to depression treatment.METHOD: A threshold for clinically meaningful panic-agoraphobic spectrum symptoms was defined by ...
https://doi.org/10.1176/appi.ajp.157.7.1101Publication date: 01 July 2000
Pages1108–1114OBJECTIVE: Increased dopaminergic neurotransmission has been implicated in the pathophysiology of bipolar disorder. However, it remains unclear whether the abnormality is due to increased dopamine release or enhanced postsynaptic receptor sensitivity. In ...
https://doi.org/10.1176/appi.ajp.157.7.1108Publication date: 01 July 2000
Pages1115–1119OBJECTIVE: The authors’ goal was to study the contribution of predeployment personality traits and exposure to traumatic events during deployment to the development of symptoms of posttraumatic stress disorder (PTSD) in individuals involved in military ...
https://doi.org/10.1176/appi.ajp.157.7.1115Publication date: 01 July 2000
Pages1120–1126OBJECTIVE: Animals exposed to stress exhibit a decrease in benzodiazepine receptor binding in the frontal cortex. No studies have examined central benzodiazepine receptor binding in patients with posttraumatic stress disorder (PTSD). The purpose of this ...
https://doi.org/10.1176/appi.ajp.157.7.1120Publication date: 01 July 2000
Pages1127–1133OBJECTIVE: The authors investigated the occurrence of pathological gambling among cocaine-dependent outpatients, its influence on short-term outcome of treatment, and comparative characteristics of patients with and without pathological gambling.METHOD: ...
https://doi.org/10.1176/appi.ajp.157.7.1127Publication date: 01 July 2000
Pages1134–1140OBJECTIVE: Recent work has underscored the role of serotonergic neurotransmission in chronic neural adaptations to cocaine dependence. The authors tested for evidence of serotonergic dysfunction during acute abstinence from cocaine, a period of high risk ...
https://doi.org/10.1176/appi.ajp.157.7.1134Publication date: 01 July 2000
Pages1141–1149OBJECTIVE: Multiple quantifiable biologic abnormalities have been localized to the hippocampus in schizophrenia. Alterations in glutamate-mediated transmission at N-methyl-d-aspartic acid (NMDA)-sensitive receptors in hippocampus have been implicated in ...
https://doi.org/10.1176/appi.ajp.157.7.1141Publication date: 01 July 2000
Pages1150–1155OBJECTIVE: The authors studied the incidence of tardive dyskinesia in elderly institutionalized patients with dementia being treated with risperidone.METHOD: After participating in a 12-week multicenter double-blind study during which they received ...
https://doi.org/10.1176/appi.ajp.157.7.1150Publication date: 01 July 2000
Pages1156–1159OBJECTIVE: The purpose of this research was to determine if adults can provide a true rating of their own childhood and current symptoms of attention deficit hyperactivity disorder (ADHD).METHOD: The authors conducted two studies. In study 1, 50 adult ...
https://doi.org/10.1176/appi.ajp.157.7.1156Brief Report
Publication date: 01 July 2000
Pages1160–1161OBJECTIVE: Obsessive-compulsive disorder (OCD) is a psychiatric condition for which strong evidence of a genetic component and serotonergic system involvement exists. Recent studies have shown that sumatriptan, a selective ligand of the serotonin (5-HT)...
https://doi.org/10.1176/appi.ajp.157.7.1160Publication date: 01 July 2000
Pages1162–1164OBJECTIVE: The authors explored the association between abuse of 3,4-methylenedioxymethamphetamine (MDMA, or “Ecstasy”) and high-risk sexual behaviors among gay and bisexual men.METHOD: An anonymous questionnaire was completed by 169 gay and bisexual men ...
https://doi.org/10.1176/appi.ajp.157.7.1162Publication date: 01 July 2000
Pages1164–1166OBJECTIVE: The authors’ goal was to determine if the reported clinical adverse interaction of flunitrazepam and buprenorphine was caused by inhibition of drug metabolism.METHOD: Inhibition of flunitrazepam metabolism by buprenorphine and norbuprenorphine ...
https://doi.org/10.1176/appi.ajp.157.7.1164Publication date: 01 July 2000
Pages1167–1169OBJECTIVE: Although several neuropsychological studies have supported the notion of frontal and parietal lobe involvement in unawareness of illness in schizophrenia, neuroanatomic differences have not been examined.METHOD: Thirty patients with ...
https://doi.org/10.1176/appi.ajp.157.7.1167Publication date: 01 July 2000
Pages1170–1172OBJECTIVE: The authors assessed the effects of nutritional deficiency during the first trimester of pregnancy on brain morphology in patients with schizophrenia.METHOD: Nine schizophrenic patients and nine healthy comparison subjects exposed during the ...
https://doi.org/10.1176/appi.ajp.157.7.1170Publication date: 01 July 2000
Pages1173–1175OBJECTIVE: Five Japanese studies, to the authors’ knowledge, without exception, have consistently shown an increased frequency of human leukocyte antigen (HLA)-DR1 in patients with schizophrenia. This suggests an association between HLA-DR1 and ...
https://doi.org/10.1176/appi.ajp.157.7.1173Publication date: 01 July 2000
Pages1175–1177OBJECTIVE: Anterior cingulate dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The authors hypothesized that integrity of the anterior cingulate may be affected in childhood PTSD.METHOD: Single voxel proton ...
https://doi.org/10.1176/appi.ajp.157.7.1175Letter to the Editor
Book Forum: Emotion and Mood Disorders
Book Forum: Ethical Issues
Book Forum: Sleeping and Dreaming
Book Forum: A Voice From the Past
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