American Journal of Psychiatry
- Volume 161
- Number 5
- May 2004
In This Issue
Editorial
Reviews and Overviews
Publication date: 01 May 2004
Pages780–796OBJECTIVE: Molecular genetic approaches provide a novel method of dissecting the heterogeneity of psychotropic drug response. These pharmacogenetic strategies offer the prospect of identifying biological predictors of psychotropic drug response and could ...
https://doi.org/10.1176/appi.ajp.161.5.780Publication date: 01 May 2004
Pages797–806OBJECTIVE: The ethics of involving decisionally incapable adults in research will continue to grow in importance as more research is conducted to address the problems of decisionally impaired persons, especially elderly persons. The authors provide an ...
https://doi.org/10.1176/appi.ajp.161.5.797Introspections
Images in Psychiatry
Article
Publication date: 01 May 2004
Pages810–817OBJECTIVE: This study compared the effectiveness of short-term dynamic psychotherapy and cognitive therapy for outpatients with cluster C personality disorders. METHOD: Patients (N=50) who met the criteria for one or more cluster C personality disorders ...
https://doi.org/10.1176/appi.ajp.161.5.810Publication date: 01 May 2004
Pages818–825OBJECTIVE: Ziprasidone is an atypical antipsychotic drug that shows a higher affinity for serotonin 5-HT2 receptors compared with dopamine D2 receptors in vitro. The affinity of ziprasidone for these receptors in vivo in patients was examined in a ...
https://doi.org/10.1176/appi.ajp.161.5.818Publication date: 01 May 2004
Pages826–835OBJECTIVE: Minimum therapeutic doses of paroxetine and citalopram produce 80% occupancy for the serotonin (5-HT) transporter (5-HTT). The authors used [11C]DASB positron emission tomography to measure occupancies of three other selective serotonin ...
https://doi.org/10.1176/appi.ajp.161.5.826Publication date: 01 May 2004
Pages836–842OBJECTIVE: Previous antidepressant maintenance trials have used the same medication from acute through maintenance phases, confounding the interpretation of prophylactic effects. The purpose of this study was to determine whether sertraline prevents the ...
https://doi.org/10.1176/appi.ajp.161.5.836Publication date: 01 May 2004
Pages843–849OBJECTIVE: This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies. METHOD: The authors studied 112 autopsy-confirmed cases of dementia with Lewy bodies in patients who had had ...
https://doi.org/10.1176/appi.ajp.161.5.843Publication date: 01 May 2004
Pages850–856OBJECTIVE: The long-term effect of counseling and support on symptoms of depression was examined in spouse-caregivers of patients with Alzheimer’s disease. METHOD: The participants were 406 spouse-caregivers of Alzheimer’s disease patients who lived at ...
https://doi.org/10.1176/appi.ajp.161.5.850Publication date: 01 May 2004
Pages857–863OBJECTIVE: The purpose of this study was to obtain nationally representative estimates of the additional time and cost associated with informal caregiving for older Americans with depressive symptoms. METHOD: Data from the 1993 Asset and Health Dynamics ...
https://doi.org/10.1176/appi.ajp.161.5.857Publication date: 01 May 2004
Pages864–871OBJECTIVE: This study examined whether there are racial differences in the prevalence of paranoid ideation and psychotic symptoms in persons age ≥55 in an urban community. METHOD: Using 1990 census data for Brooklyn, N.Y., the authors attempted to ...
https://doi.org/10.1176/appi.ajp.161.5.864Publication date: 01 May 2004
Pages872–881OBJECTIVE: Auditory selective attention involves top-down modulation of sensory processing to selectively filter relevant from irrelevant information. Patients with schizophrenia have deficits in auditory selective attention, but whether these attention ...
https://doi.org/10.1176/appi.ajp.161.5.872Publication date: 01 May 2004
Pages882–888OBJECTIVE: Structural deficits in the anterior cingulate cortex such as changes in glial cell and neuron numbers may be part of the anatomical substrate for schizophrenia and need to be investigated. The total number of neurons and glial cells in brains ...
https://doi.org/10.1176/appi.ajp.161.5.882Publication date: 01 May 2004
Pages889–895OBJECTIVE: Many studies have implicated prenatal infection in the etiology of schizophrenia. Cytokines, a family of soluble polypeptides, are critically important in the immune response to infection and in other inflammatory processes. The goal of this ...
https://doi.org/10.1176/appi.ajp.161.5.889Publication date: 01 May 2004
Pages896–902OBJECTIVE: Postmortem and neuroimaging studies of schizophrenia have reported deficits in the volume of the thalamus and its component nuclei. However, the pattern of shape change associated with such volume loss has not been investigated. In this study, ...
https://doi.org/10.1176/appi.ajp.161.5.896Publication date: 01 May 2004
Pages903–908OBJECTIVE: This study attempted to determine whether a genetic protection against cancer might be manifest in parents of offspring with schizophrenia. METHOD: Using data from the Danish Central Population Registry, the authors identified 1,999,072 parents ...
https://doi.org/10.1176/appi.ajp.161.5.903Brief Report
Publication date: 01 May 2004
Pages909–911OBJECTIVE: The authors considered the possible role of the extraneuronal monoamine transporter (uptake 2) in accounting for the delay in clinical action of norepinephrine reuptake inhibitor antidepressant drugs. METHOD: Literature searches were performed ...
https://doi.org/10.1176/appi.ajp.161.5.909Publication date: 01 May 2004
Pages912–914OBJECTIVE: The authors’ goal was to investigate the relationship between depression and HIV risk behaviors or sexually transmitted disease (STD) diagnosis at an urban STD clinic. METHOD: Using audio computer-assisted self-interview, 671 STD clinic ...
https://doi.org/10.1176/appi.ajp.161.5.912Publication date: 01 May 2004
Pages915–917OBJECTIVE: Deficits in emotional processing are evident in patients with schizophrenia. Since recent studies have indicated dysfunctions in cortical areas involved in face processing, this study investigated the early processing of faces in schizophrenia ...
https://doi.org/10.1176/appi.ajp.161.5.915Publication date: 01 May 2004
Pages918–920OBJECTIVE: This study assessed the impact of risperidone on growth and sexual maturation. METHOD: The pooled database of five studies included 700 children ages 5–15 years with disruptive behavior disorders. All evaluable patients had received risperidone ...
https://doi.org/10.1176/appi.ajp.161.5.918Publication date: 01 May 2004
Pages920–922OBJECTIVE: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. METHOD: The Dublin Psychiatric Case Register was used to identify subjects with ...
https://doi.org/10.1176/appi.ajp.161.5.920Letter to the Editor
Book Forum: Positive Approaches
Book Forum: Subjective Experiences
Book Forum: Treatment Guides
Book Forum: Neuropsychology
Corrections
Correction
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