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American Journal of Psychiatry

  • Volume 161
  • Number 6
  • June 2004

In This Issue

Editorial

Reviews and Overviews

Publication date: 01 June 2004

Pages946–954

OBJECTIVE: Changes in DSM-IV were guided by empirical data that mostly focused on improving diagnostic validity and reliability. Although many changes were made explicitly to improve clinical utility, no formal effort was made to empirically determine ...

https://doi.org/10.1176/appi.ajp.161.6.946

Publication date: 01 June 2004

Pages955–963

OBJECTIVE: This article explores the potential of community intervention perspectives for increasing the relevance, reach, and public health impact of mental health services research. METHOD: The authors reviewed community intervention strategies, ...

https://doi.org/10.1176/appi.ajp.161.6.955

Introspections

Clinical Case Conference

Images in Psychiatry

Article

Publication date: 01 June 2004

Pages975–984

OBJECTIVE: Four studies using identical protocols evaluated the safety and efficacy of four novel, evidence-based targets for antipsychotic agents: a neurokinin (NK3) antagonist (SR142801), a serotonin 2A/2C (5-HT2A/2C) antagonist (SR46349B), a central ...

https://doi.org/10.1176/appi.ajp.161.6.975

Publication date: 01 June 2004

Pages996–1003

OBJECTIVE: The profile of neuropsychological impairment associated with unipolar psychotic depression remains unclear. The authors used a neuropsychological test battery to characterize the neuropsychiatric profile of patients with unipolar psychotic ...

https://doi.org/10.1176/appi.ajp.161.6.996

Publication date: 01 June 2004

Pages1004–1015

OBJECTIVE: Neuropsychological studies have demonstrated verbal episodic memory deficits in schizophrenia during word encoding and retrieval. This study examined neural substrates of memory in an analysis that controlled for successful retrieval. METHOD: ...

https://doi.org/10.1176/appi.ajp.161.6.1004

Publication date: 01 June 2004

Pages1016–1022

OBJECTIVE: Several structural and functional brain imaging studies have pointed to a disturbance of thalamic subnuclei in patients with schizophrenia. The dopamine hypothesis of schizophrenia has, however, not been thoroughly examined in terms of this ...

https://doi.org/10.1176/appi.ajp.161.6.1016

Publication date: 01 June 2004

Pages1023–1029

OBJECTIVE: Structural and functional studies implicate multiple brain lesions as a basis for a functional dysconnectivity underlying the cognitive and symptom profiles in schizophrenia. The aim of this study was to examine the hypothesis that early-onset ...

https://doi.org/10.1176/appi.ajp.161.6.1023

Publication date: 01 June 2004

Pages1030–1037

OBJECTIVE: The authors prospectively investigated neurological abnormalities in 75 young adult offspring of mothers with psychotic disorders and 91 offspring of comparison mothers with no psychosis history. They also studied the stability of these ...

https://doi.org/10.1176/appi.ajp.161.6.1030

Publication date: 01 June 2004

Pages1038–1048

OBJECTIVE: Compulsive hoarding and saving symptoms, found in many patients with obsessive-compulsive disorder (OCD), are part of a discrete clinical syndrome that includes indecisiveness, disorganization, perfectionism, procrastination, and avoidance and ...

https://doi.org/10.1176/appi.ajp.161.6.1038

Publication date: 01 June 2004

Pages1057–1065

OBJECTIVE: This study evaluated the efficacy and safety of risperidone monotherapy in the treatment of acute bipolar mania. METHOD: Patients with DSM-IV bipolar I disorder experiencing an acute manic episode (baseline Young Mania Rating Scale score ≥20) ...

https://doi.org/10.1176/appi.ajp.161.6.1057

Publication date: 01 June 2004

Pages1066–1078

OBJECTIVE: The available data on antidepressant levels in nursing infants were analyzed in order to calculate average infant drug levels and determine what factors influence plasma drug levels in breast-feeding infants of mothers treated with ...

https://doi.org/10.1176/appi.ajp.161.6.1066

Publication date: 01 June 2004

Pages1079–1083

OBJECTIVE: Open-label trials with the selective serotonin reuptake inhibitor citalopram suggest that this agent is effective and safe for the treatment of depressive symptoms in children and adolescents. The current study investigated the efficacy and ...

https://doi.org/10.1176/appi.ajp.161.6.1079

Publication date: 01 June 2004

Pages1090–1095

OBJECTIVE: Poststroke depression has been linked to higher mortality after stroke. However, the effect of other mental health conditions on poststroke mortality has not been examined. The objective of this study was to evaluate the effect of poststroke ...

https://doi.org/10.1176/appi.ajp.161.6.1090

Publication date: 01 June 2004

Pages1096–1102

OBJECTIVE: Few studies have examined pathological changes in serotonergic neurons in depression, particularly in elderly patients and in elderly patients in which depression occurs in dementia. The authors hypothesized that greater neurofibrillary ...

https://doi.org/10.1176/appi.ajp.161.6.1096

Publication date: 01 June 2004

Pages1103–1109

OBJECTIVE: This study examined the relationship between utilization management techniques and psychiatrists’ treatment plan modifications. METHOD: Nationally representative data on 1,843 patients treated by 615 psychiatrists participating in the American ...

https://doi.org/10.1176/appi.ajp.161.6.1103

Brief Report

Publication date: 01 June 2004

Pages1110–1112

OBJECTIVE: Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in the catechol O-methyltransferase (COMT) gene ...

https://doi.org/10.1176/appi.ajp.161.6.1110

Publication date: 01 June 2004

Pages1113–1115

OBJECTIVE: Randomized controlled trials have suggested that at least one atypical antipsychotic may be associated with an increased risk of stroke in older people with dementia. This study examined the association between atypical antipsychotic use and ...

https://doi.org/10.1176/appi.ajp.161.6.1113

Publication date: 01 June 2004

Pages1116–1118

OBJECTIVE: Glutamate and glutamine were examined in vivo in nonpsychotic adolescents at high genetic risk for schizophrenia by using 3-T proton magnetic resonance spectroscopy (1H-MRS). METHOD: Spectra from the right medial frontal lobe of 20 adolescents ...

https://doi.org/10.1176/appi.ajp.161.6.1116

Publication date: 01 June 2004

Pages1119–1121

OBJECTIVE: Few neuroimaging studies of generalized anxiety disorder have been conducted. The present study used proton magnetic resonance spectroscopy to assess concentrations of N-acetylaspartate, often considered a marker of neuronal viability, in ...

https://doi.org/10.1176/appi.ajp.161.6.1119

Publication date: 01 June 2004

Pages1121–1124

OBJECTIVE: The superior temporal gyrus, a heteromodal auditory and language association cortex, has been found to be smaller in patients with schizophrenia than in normal subjects. However, genetic and/or neurodevelopmental underpinnings of superior ...

https://doi.org/10.1176/appi.ajp.161.6.1121

Letter to the Editor

Book Forum: Psychotherapy

Book Forum: Neuroscience and Psychiatry

Book Forum: Child Psychiatry

Book Forum: Forensic Psychiatry

Corrections

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