American Journal of Psychiatry
- Volume 161
- Number 6
- June 2004
In This Issue
Editorial
Reviews and Overviews
Publication date: 01 June 2004
Pages946–954OBJECTIVE: Changes in DSM-IV were guided by empirical data that mostly focused on improving diagnostic validity and reliability. Although many changes were made explicitly to improve clinical utility, no formal effort was made to empirically determine ...
https://doi.org/10.1176/appi.ajp.161.6.946Publication date: 01 June 2004
Pages955–963OBJECTIVE: This article explores the potential of community intervention perspectives for increasing the relevance, reach, and public health impact of mental health services research. METHOD: The authors reviewed community intervention strategies, ...
https://doi.org/10.1176/appi.ajp.161.6.955Introspections
Clinical Case Conference
Images in Psychiatry
Article
Publication date: 01 June 2004
Pages975–984OBJECTIVE: Four studies using identical protocols evaluated the safety and efficacy of four novel, evidence-based targets for antipsychotic agents: a neurokinin (NK3) antagonist (SR142801), a serotonin 2A/2C (5-HT2A/2C) antagonist (SR46349B), a central ...
https://doi.org/10.1176/appi.ajp.161.6.975Publication date: 01 June 2004
Pages985–995OBJECTIVE: The effect of antipsychotic medication on neurocognitive function remains controversial, especially since most previous work has compared the effects of novel antipsychotic medications with those of high doses of conventional medications. This ...
https://doi.org/10.1176/appi.ajp.161.6.985Publication date: 01 June 2004
Pages996–1003OBJECTIVE: The profile of neuropsychological impairment associated with unipolar psychotic depression remains unclear. The authors used a neuropsychological test battery to characterize the neuropsychiatric profile of patients with unipolar psychotic ...
https://doi.org/10.1176/appi.ajp.161.6.996Publication date: 01 June 2004
Pages1004–1015OBJECTIVE: Neuropsychological studies have demonstrated verbal episodic memory deficits in schizophrenia during word encoding and retrieval. This study examined neural substrates of memory in an analysis that controlled for successful retrieval. METHOD: ...
https://doi.org/10.1176/appi.ajp.161.6.1004Publication date: 01 June 2004
Pages1016–1022OBJECTIVE: Several structural and functional brain imaging studies have pointed to a disturbance of thalamic subnuclei in patients with schizophrenia. The dopamine hypothesis of schizophrenia has, however, not been thoroughly examined in terms of this ...
https://doi.org/10.1176/appi.ajp.161.6.1016Publication date: 01 June 2004
Pages1023–1029OBJECTIVE: Structural and functional studies implicate multiple brain lesions as a basis for a functional dysconnectivity underlying the cognitive and symptom profiles in schizophrenia. The aim of this study was to examine the hypothesis that early-onset ...
https://doi.org/10.1176/appi.ajp.161.6.1023Publication date: 01 June 2004
Pages1030–1037OBJECTIVE: The authors prospectively investigated neurological abnormalities in 75 young adult offspring of mothers with psychotic disorders and 91 offspring of comparison mothers with no psychosis history. They also studied the stability of these ...
https://doi.org/10.1176/appi.ajp.161.6.1030Publication date: 01 June 2004
Pages1038–1048OBJECTIVE: Compulsive hoarding and saving symptoms, found in many patients with obsessive-compulsive disorder (OCD), are part of a discrete clinical syndrome that includes indecisiveness, disorganization, perfectionism, procrastination, and avoidance and ...
https://doi.org/10.1176/appi.ajp.161.6.1038Publication date: 01 June 2004
Pages1049–1056OBJECTIVE: The authors investigated structural abnormalities in brain regions comprising cortical-striatal-thalamic-cortical loops in pediatric patients with obsessive-compulsive disorder (OCD). METHOD: Volumes of the caudate nucleus, putamen, and globus ...
https://doi.org/10.1176/appi.ajp.161.6.1049Publication date: 01 June 2004
Pages1057–1065OBJECTIVE: This study evaluated the efficacy and safety of risperidone monotherapy in the treatment of acute bipolar mania. METHOD: Patients with DSM-IV bipolar I disorder experiencing an acute manic episode (baseline Young Mania Rating Scale score ≥20) ...
https://doi.org/10.1176/appi.ajp.161.6.1057Publication date: 01 June 2004
Pages1066–1078OBJECTIVE: The available data on antidepressant levels in nursing infants were analyzed in order to calculate average infant drug levels and determine what factors influence plasma drug levels in breast-feeding infants of mothers treated with ...
https://doi.org/10.1176/appi.ajp.161.6.1066Publication date: 01 June 2004
Pages1079–1083OBJECTIVE: Open-label trials with the selective serotonin reuptake inhibitor citalopram suggest that this agent is effective and safe for the treatment of depressive symptoms in children and adolescents. The current study investigated the efficacy and ...
https://doi.org/10.1176/appi.ajp.161.6.1079Publication date: 01 June 2004
Pages1084–1089OBJECTIVE: The authors attempted to estimate the occurrence, frequency, and pattern (winter versus summer) of seasonal affective disorder in African American college students. They hypothesized that winter seasonal affective disorder would be more ...
https://doi.org/10.1176/appi.ajp.161.6.1084Publication date: 01 June 2004
Pages1090–1095OBJECTIVE: Poststroke depression has been linked to higher mortality after stroke. However, the effect of other mental health conditions on poststroke mortality has not been examined. The objective of this study was to evaluate the effect of poststroke ...
https://doi.org/10.1176/appi.ajp.161.6.1090Publication date: 01 June 2004
Pages1096–1102OBJECTIVE: Few studies have examined pathological changes in serotonergic neurons in depression, particularly in elderly patients and in elderly patients in which depression occurs in dementia. The authors hypothesized that greater neurofibrillary ...
https://doi.org/10.1176/appi.ajp.161.6.1096Publication date: 01 June 2004
Pages1103–1109OBJECTIVE: This study examined the relationship between utilization management techniques and psychiatrists’ treatment plan modifications. METHOD: Nationally representative data on 1,843 patients treated by 615 psychiatrists participating in the American ...
https://doi.org/10.1176/appi.ajp.161.6.1103Brief Report
Publication date: 01 June 2004
Pages1110–1112OBJECTIVE: Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in the catechol O-methyltransferase (COMT) gene ...
https://doi.org/10.1176/appi.ajp.161.6.1110Publication date: 01 June 2004
Pages1113–1115OBJECTIVE: Randomized controlled trials have suggested that at least one atypical antipsychotic may be associated with an increased risk of stroke in older people with dementia. This study examined the association between atypical antipsychotic use and ...
https://doi.org/10.1176/appi.ajp.161.6.1113Publication date: 01 June 2004
Pages1116–1118OBJECTIVE: Glutamate and glutamine were examined in vivo in nonpsychotic adolescents at high genetic risk for schizophrenia by using 3-T proton magnetic resonance spectroscopy (1H-MRS). METHOD: Spectra from the right medial frontal lobe of 20 adolescents ...
https://doi.org/10.1176/appi.ajp.161.6.1116Publication date: 01 June 2004
Pages1119–1121OBJECTIVE: Few neuroimaging studies of generalized anxiety disorder have been conducted. The present study used proton magnetic resonance spectroscopy to assess concentrations of N-acetylaspartate, often considered a marker of neuronal viability, in ...
https://doi.org/10.1176/appi.ajp.161.6.1119Publication date: 01 June 2004
Pages1121–1124OBJECTIVE: The superior temporal gyrus, a heteromodal auditory and language association cortex, has been found to be smaller in patients with schizophrenia than in normal subjects. However, genetic and/or neurodevelopmental underpinnings of superior ...
https://doi.org/10.1176/appi.ajp.161.6.1121Publication date: 01 June 2004
Pages1125–1127OBJECTIVE: The authors examined the developmental impact and temporal characteristics of risperidone-associated weight change. METHOD: Weight change was measured for 63 children and adolescents with autism treated with risperidone for 6 months. Change in ...
https://doi.org/10.1176/appi.ajp.161.6.1125Letter to the Editor
Book Forum: Psychotherapy
Book Forum: Neuroscience and Psychiatry
Book Forum: Child Psychiatry
Book Forum: Forensic Psychiatry
Corrections
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