American Journal of Psychiatry
- Volume 163
- Number 12
- December 2006
In This Issue
Editorial
Special Article
Images in Neuroscience
Reviews and Overviews
Publication date: 01 December 2006
Pages2047–2056Objective: Second-generation antipsychotics make up one of the fastest growing segments of the rapidly growing pharmaceutical sector. Given limited health care resources, assessment of the value for the cost of second-generation antipsychotics ...
https://doi.org/10.1176/ajp.2006.163.12.2047Introspections
Treatment in Psychiatry
Clinical Case Conference
Images in Psychiatry
Article
Publication date: 01 December 2006
Pages2072–2079Objective: Second-generation, or atypical, antipsychotics effectively treat psychiatric illness in children and adolescents. However, weight gain and abnormalities in insulin sensitivity, including diabetes, complicate this therapy. ...
https://doi.org/10.1176/ajp.2006.163.12.2072Publication date: 01 December 2006
Pages2080–2089BACKGROUND: Second-generation antipsychotics have largely replaced first-generation antipsychotics for the treatment of schizophrenia, but a large-scale cost/effectiveness analysis has not been attempted. Method: Patients ...
https://doi.org/10.1176/ajp.2006.163.12.2080Publication date: 01 December 2006
Pages2090–2095Objective: Changing antipsychotics is common despite the dearth of information on risks and benefits associated with medication changes. The authors examined phase 1 findings from the Clinical Antipsychotic Trials of Intervention Effectiveness (...
https://doi.org/10.1176/ajp.2006.163.12.2090Publication date: 01 December 2006
Pages2096–2102Objective: The authors compared 4-month treatment outcomes for olanzapine versus risperidone in patients with first-episode schizophrenia spectrum disorders. Method: One hundred twelve subjects (70% male; mean age=23.3 years ...
https://doi.org/10.1176/ajp.2006.163.12.2096Publication date: 01 December 2006
Pages2103–2110Objective: Magnetic resonance imaging (MRI) studies of schizophrenia reveal temporal lobe structural brain abnormalities in the superior temporal gyrus and the amygdala-hippocampal complex. However, the middle and inferior temporal gyri have ...
https://doi.org/10.1176/ajp.2006.163.12.2103Publication date: 01 December 2006
Pages2111–2118Objective: Cognitive impairments associated with schizophrenia might be expected to have a marked impact on the ability to produce coherent speech, yet associations between cognitive performance and speech disorder have typically been weak. ...
https://doi.org/10.1176/ajp.2006.163.12.2111Publication date: 01 December 2006
Pages2119–2125Objective: This study evaluated a 10-week Internet-based bibliotherapy self-help program with short weekly telephone calls for people suffering from panic disorder with or without agoraphobia. Method: After the authors ...
https://doi.org/10.1176/ajp.2006.163.12.2119Publication date: 01 December 2006
Pages2126–2133Objective: This trial assessed two novel nonpharmaceutical treatments for winter depression—naturalistic dawn simulation and high-density negative air ionization—delivered during the final hours of sleep. Method: The ...
https://doi.org/10.1176/ajp.2006.163.12.2126Publication date: 01 December 2006
Pages2134–2140Objective: The authors investigated whether the transition from licit drug use to marijuana use is determined by particular risk factors, as specified by the gateway hypothesis. They also evaluated the accuracy of the “gateway sequence” (...
https://doi.org/10.1176/ajp.2006.163.12.2134Publication date: 01 December 2006
Pages2141–2147Objective: The authors examined changes in the prevalence of major depression in the United States between 1991–1992 and 2001–2002 and sought to determine whether changes in depression rates were associated with changes in rates of comorbid ...
https://doi.org/10.1176/ajp.2006.163.12.2141Publication date: 01 December 2006
Pages2148–2156Objective: The serotonin transporter gene (SLC6A4) is a strong autism candidate gene because of its association with anxiety, aggression and attention, and the effectiveness of selective serotonin reuptake inhibitors (SSRIs) in treating certain ...
https://doi.org/10.1176/ajp.2006.163.12.2148Publication date: 01 December 2006
Pages2157–2163Objective: The corpus callosum is the primary anatomical substrate for interhemispheric communication, which is important for a range of adaptive and cognitive behaviors in early development. Previous studies that have measured the corpus ...
https://doi.org/10.1176/ajp.2006.163.12.2157Publication date: 01 December 2006
Pages2164–2169Objective: Studies of subjects with dementia of the Alzheimer type have reported correlations between increases in activity of the hypothalamic-pituitary-adrenal (HPA) axis and hippocampal degeneration. In this study, the authors sought to ...
https://doi.org/10.1176/ajp.2006.163.12.2164Publication date: 01 December 2006
Pages2170–2177Objective: The purpose of this article was to estimate relative risks of all-cause mortality associated with parental psychiatric disorder based on offspring age (up to 25 years of age), parental diagnosis, maternal versus paternal disorder, ...
https://doi.org/10.1176/ajp.2006.163.12.2170Brief Report
Publication date: 01 December 2006
Pages2178–2180Objective: The authors examined whether maternal exposure to herpes virus type 2 is associated with risk for adult schizophrenia. Method: The authors studied a large birth cohort, born 1959–1967, with follow-up for ...
https://doi.org/10.1176/ajp.2006.163.12.2178Publication date: 01 December 2006
Pages2181–2183Objective: This study assessed the stability of binge eating disorder in a community sample. Method: The authors interviewed 888 first-degree relatives of 300 overweight or obese probands (150 with binge eating disorder and ...
https://doi.org/10.1176/ajp.2006.163.12.2181Publication date: 01 December 2006
Pages2184–2186Objective: The purpose of this study was to investigate the acute effects of modafinil on prefrontal activation and cognitive control of motor activity in people with schizophrenia and prominent negative symptoms. Method: In ...
https://doi.org/10.1176/ajp.2006.163.12.2184Publication date: 01 December 2006
Pages2186–2188Objective: The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD). Method: Veterans with chronic PTSD who were medication-free or ...
https://doi.org/10.1176/ajp.2006.163.12.2186Publication date: 01 December 2006
Pages2189–2192Objective: The neural basis for autistic spectrum disorders is unclear, but abnormalities in the development of limbic areas and of glutamate have been suggested. Proton magnetic resonance spectroscopy ( 1 H-MRS) can be used ...
https://doi.org/10.1176/ajp.2006.163.12.2189Letters to the Editor
Corrections
Book Forum
Books Received
In Appreciation
Annual Author Index
Past Issues
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