American Journal of Psychiatry
- Volume 161
- Number 3
- March 2004
In This Issue
Editorial
Reviews and Overviews
Publication date: 01 March 2004
Pages398–413OBJECTIVE: This overview focuses on neurobiological abnormalities found in subjects with schizotypal personality disorder, the prototype of the schizophrenia spectrum disorders, and chronic schizophrenia in the context of common vulnerabilities shared by ...
https://doi.org/10.1176/appi.ajp.161.3.398Publication date: 01 March 2004
Pages414–425OBJECTIVE: Based on lower rates of acute extrapyramidal side effects associated with second-generation antipsychotics, compared to first-generation antipsychotics, and based on preliminary data, second-generation antipsychotics are expected to cause less ...
https://doi.org/10.1176/appi.ajp.161.3.414Images in Neuroscience
Introspections
Clinical Case Conference
Images in Psychiatry
Article
Publication date: 01 March 2004
Pages437–443OBJECTIVE: Individuals with a differing number of past suicide attempts are generally considered a homogeneous group, despite emerging evidence to the contrary. The current study aimed to test the hypothesis that multiple suicide attempters would exhibit ...
https://doi.org/10.1176/appi.ajp.161.3.437Publication date: 01 March 2004
Pages444–451OBJECTIVE: Borrowing from recent dimensional models of psychopathology, the authors conducted analyses that optimized the common variance shared by internalizing (depression, anxiety) and externalizing (antisocial personality, substance dependence) ...
https://doi.org/10.1176/appi.ajp.161.3.444Publication date: 01 March 2004
Pages452–458OBJECTIVE: Data on risk factors for suicide in blacks in the United States are needed, given the dramatic increase in the black suicide rate from 1980 to 1997. The 1993 National Mortality Followback Survey represented an unprecedented opportunity to ...
https://doi.org/10.1176/appi.ajp.161.3.452Publication date: 01 March 2004
Pages459–465OBJECTIVE: Men are more violent than women in the general population, but this has not been found to be the case among psychiatric inpatients. The reason for this exception is poorly understood. The present study investigated gender differences in violent ...
https://doi.org/10.1176/appi.ajp.161.3.459Publication date: 01 March 2004
Pages466–472OBJECTIVE: The authors examined the relationship of neurocognitive function with duration of untreated psychosis, premorbid illness factors, and clinical symptoms to determine whether long duration of untreated psychosis independently compromises ...
https://doi.org/10.1176/appi.ajp.161.3.466Publication date: 01 March 2004
Pages473–479OBJECTIVE: Follow-up studies have found that a substantial number of patients with schizophrenia achieve full recovery (i.e., sustained improvement in both symptoms and social/vocational functioning) when examined decades after an index admission. This ...
https://doi.org/10.1176/appi.ajp.161.3.473Publication date: 01 March 2004
Pages480–489OBJECTIVE: The authors investigated impaired differentiation of limbic-prefrontal systems by autonomic arousal in schizophrenia. It was predicted that paranoid patients would be distinguished by a disjunction of hyperarousal but reduced amygdala and ...
https://doi.org/10.1176/appi.ajp.161.3.480Publication date: 01 March 2004
Pages490–500OBJECTIVE: It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response variability (“noise”) is thought to result from ...
https://doi.org/10.1176/appi.ajp.161.3.490Publication date: 01 March 2004
Pages501–506OBJECTIVE: The purpose of the study was to assess the independent influences of gender and cannabis use on milestones of early course in schizophrenia. METHOD: In this population-based, first-contact incidence study conducted in The Hague, the Netherlands,...
https://doi.org/10.1176/appi.ajp.161.3.501Publication date: 01 March 2004
Pages507–514OBJECTIVE: Accurate information regarding the psychopathological consequences of surviving traumatic injury is of great importance for effective health service design and planning. Regrettably, existing studies vary dramatically in reported prevalence ...
https://doi.org/10.1176/appi.ajp.161.3.507Publication date: 01 March 2004
Pages515–524OBJECTIVE: The efficacy of repetitive transcranial magnetic stimulation (rTMS) of the right prefrontal cortex was studied in patients with posttraumatic stress disorder (PTSD) under double-blind, placebo-controlled conditions. METHOD: Twenty-four patients ...
https://doi.org/10.1176/appi.ajp.161.3.515Publication date: 01 March 2004
Pages525–531OBJECTIVE: A functional polymorphism has been described in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SERT). This polymorphism has two common alleles, designated as long and short. Each allele has been linked ...
https://doi.org/10.1176/appi.ajp.161.3.525Publication date: 01 March 2004
Pages532–538OBJECTIVE: Alzheimer’s disease pathology includes both histologic changes and neurotransmitter deficits. The cholinergic deficit contributes to both cognitive and behavioral disturbances, and cholinesterase inhibitors may improve behavior in Alzheimer’s ...
https://doi.org/10.1176/appi.ajp.161.3.532Publication date: 01 March 2004
Pages539–546OBJECTIVE: The broader autism phenotype includes relatives of individuals with autism who display social and language deficits that are qualitatively similar to those of autism but less severe. In previous studies of monozygotic twins discordant for ...
https://doi.org/10.1176/appi.ajp.161.3.539Publication date: 01 March 2004
Pages547–555OBJECTIVE: In a previous controlled study of offspring at risk for anxiety disorders, the authors found that parental panic disorder with comorbid major depression was associated with child behavioral inhibition, the temperamental tendency to be quiet and ...
https://doi.org/10.1176/appi.ajp.161.3.547Publication date: 01 March 2004
Pages556–561OBJECTIVE: The authors’ goal was to determine whether treatments known to be effective for bulimia nervosa in specialized treatment centers can be used successfully in primary health care settings. They examined the benefits of two treatments for bulimia: ...
https://doi.org/10.1176/appi.ajp.161.3.556Brief Report
Publication date: 01 March 2004
Pages562–563OBJECTIVE: Attempted suicide is the strongest known predictor of completed suicide. However, suicide risk declines over time after an attempt, and it is unclear how long the risk persists. Risk estimates are almost exclusively based on studies of less ...
https://doi.org/10.1176/appi.ajp.161.3.562Publication date: 01 March 2004
Pages564–566OBJECTIVE: Previous studies suggest that the dopamine agonist pramipexole may possess antidepressant properties. The authors conducted a preliminary randomized, placebo-controlled trial to determine the safety and antidepressant efficacy of pramipexole in ...
https://doi.org/10.1176/appi.ajp.161.3.564Publication date: 01 March 2004
Pages567–569OBJECTIVE: This study examined the association between the dietary intake of omega-3 fatty acids and low mood, major depression, and suicide. METHOD: A total of 29,133 men ages 50 to 69 years participated in a population-based trial in Finland. The intake ...
https://doi.org/10.1176/appi.ajp.161.3.567Publication date: 01 March 2004
Pages569–572OBJECTIVE: Association between the low-activity variant of a polymorphism in the transcriptional control region of the serotonin transporter (5-HTTLPR) and neuroticism or harm avoidance was found in several but not all studies. The authors analyzed the ...
https://doi.org/10.1176/appi.ajp.161.3.569Publication date: 01 March 2004
Pages573–575OBJECTIVE: This study used diffusion tensor imaging to examine fractional anisotropy in the anterior cingulum and posterior cingulum bundles in patients with schizophrenia. METHOD: Twenty-one male patients and 20 healthy comparison men were studied. ...
https://doi.org/10.1176/appi.ajp.161.3.573Publication date: 01 March 2004
Pages576–578OBJECTIVE: The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge. METHOD: ...
https://doi.org/10.1176/appi.ajp.161.3.576Letter to the Editor
Book Forum: Psychoneuroimmunology
Book Forum: Psychometric Testing
Book Forum: Neural Mechanisms of Illness
Book Forum: Substance Abuse and Comorbidity
Book Forum: Epidemiology
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