American Journal of Psychiatry
- Volume 158
- Number 8
- August 2001
Editorial
Reviews and Overviews
Publication date: 01 August 2001
Pages1184–1190OBJECTIVE: Alcohol use disorders and other substance use disorders are extremely common among patients with posttraumatic stress disorder (PTSD). This article reviews studies pertaining to the epidemiology, clinical phenomenology, and pathophysiology of ...
https://doi.org/10.1176/appi.ajp.158.8.1184Publication date: 01 August 2001
Pages1191–1198OBJECTIVE: The authors reviewed the pathogenesis of cocaine-related cerebral ischemia, appraised current knowledge of its sequelae, and assessed the role of putative therapeutic agents, particularly dihydropyridine-class calcium channel antagonists. ...
https://doi.org/10.1176/appi.ajp.158.8.1191Images in Neuroscience
Clinical Case Conference
Images in Psychiatry
Article
Publication date: 01 August 2001
Pages1206–1214OBJECTIVE: A positron emission tomography (PET) study has suggested that dopamine transporter density of the caudate/putamen is reduced in methamphetamine users. The authors measured nucleus accumbens and prefrontal cortex density, in addition to caudate/...
https://doi.org/10.1176/appi.ajp.158.8.1206Publication date: 01 August 2001
Pages1215–1219OBJECTIVE: Although suicidal behavior is frequent among cocaine-dependent patients, it has been little studied. Therefore, the author examined the characteristics of cocaine-dependent patients who had attempted suicide. METHOD: Cocaine-dependent patients ...
https://doi.org/10.1176/appi.ajp.158.8.1215Publication date: 01 August 2001
Pages1220–1226OBJECTIVE: The central nervous system representation of social phobia (social anxiety disorder) is largely unknown. The aim of this study was to examine brain activity during symptom provocation in social phobics. METHOD: Positron emission tomography with ...
https://doi.org/10.1176/appi.ajp.158.8.1220Publication date: 01 August 2001
Pages1227–1230OBJECTIVE: Despite evidence of hyperresponsive peripheral and central nervous system (CNS) noradrenergic activity in posttraumatic stress disorder (PTSD), direct measures of CNS norepinephrine in PTSD have been lacking. The goal of this study was to ...
https://doi.org/10.1176/appi.ajp.158.8.1227Publication date: 01 August 2001
Pages1231–1238OBJECTIVE: The authors’ goal was to identify predictors of 1-year outcomes for consecutive patients in a hospital emergency department following motor vehicle accidents and to describe the prevalence and course of four types of psychiatric outcomes after ...
https://doi.org/10.1176/appi.ajp.158.8.1231Publication date: 01 August 2001
Pages1239–1247OBJECTIVE: Peritraumatic dissociation has been associated with subsequent development of posttraumatic stress disorder, but supporting data have been largely retrospective. The current study was designed to assess the nature and prevalence of dissociative ...
https://doi.org/10.1176/ajp.158.8.1239Publication date: 01 August 2001
Pages1239–1247OBJECTIVE: Peritraumatic dissociation has been associated with subsequent development of posttraumatic stress disorder, but supporting data have been largely retrospective. The current study was designed to assess the nature and prevalence of dissociative ...
https://doi.org/10.1176/ajp.158.8.1239bPublication date: 01 August 2001
Pages1239–1247OBJECTIVE: Peritraumatic dissociation has been associated with subsequent development of posttraumatic stress disorder, but supporting data have been largely retrospective. The current study was designed to assess the nature and prevalence of dissociative ...
https://doi.org/10.1176/appi.ajp.158.8.1239Publication date: 01 August 2001
Pages1248–1251OBJECTIVE: The authors prospectively explored whether a reduction in the volume of the hippocampus occurs in recent trauma survivors who develop posttraumatic stress disorder (PTSD). METHOD: Thirty-seven survivors of traumatic events were assessed within ...
https://doi.org/10.1176/appi.ajp.158.8.1248Publication date: 01 August 2001
Pages1252–1257OBJECTIVE: This study investigated whether cancer patients with and without major depression exhibit immune system abnormalities similar to those reported in medically healthy, depressed subjects without cancer. METHOD: The study subjects consisted of ...
https://doi.org/10.1176/appi.ajp.158.8.1252Publication date: 01 August 2001
Pages1258–1264OBJECTIVE: Symptomatic overlap between affective disorders and schizophrenia has long been noted. More recently, family and linkage studies have provided some evidence for overlapping genetic susceptibility between bipolar disorder and schizophrenia. If ...
https://doi.org/10.1176/appi.ajp.158.8.1258Publication date: 01 August 2001
Pages1265–1270OBJECTIVE: To assess the risk for subsequent development of mania or hypomania, the authors conducted a 15-year prospective follow-up study of a large, young cohort of patients originally hospitalized for unipolar major depression. METHOD: Patients who ...
https://doi.org/10.1176/appi.ajp.158.8.1265Publication date: 01 August 2001
Pages1271–1275OBJECTIVE: The purpose of this study was to determine if fear of an increased risk of attempted suicide in placebo groups participating in placebo-controlled studies is an argument against the performance of placebo-controlled trials in studies of major ...
https://doi.org/10.1176/appi.ajp.158.8.1271Publication date: 01 August 2001
Pages1276–1285OBJECTIVE: This study examined the interrelationship between negative symptoms, orofacial tardive dyskinesia, and specific neurocognitive processes, particularly those involved in memory and executive function, in patients with schizophrenia. METHOD: A ...
https://doi.org/10.1176/appi.ajp.158.8.1276Publication date: 01 August 2001
Pages1286–1290OBJECTIVE: Impaired olfactory identification ability has previously been demonstrated in patients with schizophrenia. This study assessed olfactory function in psychotic and nonpsychotic members of multigenerational families with familial schizophrenia to ...
https://doi.org/10.1176/appi.ajp.158.8.1286Publication date: 01 August 2001
Pages1291–1298OBJECTIVE: Although childhood-onset schizophrenia is relatively rare, a sizable group of children with severe emotional disturbances have transient psychotic symptoms that fall outside of current syndrome boundaries. The relationship of this group of ...
https://doi.org/10.1176/appi.ajp.158.8.1291Publication date: 01 August 2001
Pages1299–1304OBJECTIVE: The superior temporal gyrus is associated with developmental mechanisms of brain lateralization and the pathogenesis of language-related schizophrenic symptoms. It therefore lends itself to investigation of developmental deviance in the early ...
https://doi.org/10.1176/appi.ajp.158.8.1299Publication date: 01 August 2001
Pages1305–1313OBJECTIVE: This prospective, double-blind, multicenter, parallel-group study compared the efficacy and safety of therapeutic doses of clozapine and risperidone in patients with severe chronic schizophrenia and poor previous treatment response. METHOD: ...
https://doi.org/10.1176/appi.ajp.158.8.1305Brief Report
Publication date: 01 August 2001
Pages1314–1316OBJECTIVE: Using proton magnetic resonance spectroscopic imaging, the authors measured thalamic N-acetylaspartate (NAA) concentrations in patients with schizophrenia. METHOD: The study included 15 schizophrenic patients on a stable medication regimen and ...
https://doi.org/10.1176/appi.ajp.158.8.1314Publication date: 01 August 2001
Pages1316–1319OBJECTIVE: This study investigated the effect on brain morphology of an interleukin-1β genetic polymorphism (C→T transition at position –511) in patients with schizophrenia. METHOD: In vivo magnetic resonance imaging and genotype analysis were used in the ...
https://doi.org/10.1176/appi.ajp.158.8.1316Publication date: 01 August 2001
Pages1319–1321OBJECTIVE: Disturbed sensory gating has been related to attention deficit and greater distractibility in patients with schizophrenia, and dysfunction of the alpha-7 subunit of the cholinergic nicotinic receptor has been discussed as its biological basis. ...
https://doi.org/10.1176/appi.ajp.158.8.1319Publication date: 01 August 2001
Pages1321–1323OBJECTIVE: The authors assessed frontotemporal function in patients with geriatric depression, a debilitating and increasingly prevalent disorder that has not been examined with brain activation paradigms. METHOD: Six depressed elderly patients and five ...
https://doi.org/10.1176/appi.ajp.158.8.1321Publication date: 01 August 2001
Pages1324–1326OBJECTIVE: The authors sought to determine whether the manic/mixed episode distinction in patients with bipolar disorder runs true over time. METHOD: Over an 11-year period, the observed distribution of manic and mixed episodes (N=1,224) for patients with ...
https://doi.org/10.1176/appi.ajp.158.8.1324Publication date: 01 August 2001
Pages1326–1328OBJECTIVE: The authors investigated the relationship between anxiety—a facet of the Revised NEO Personality Inventory dimension of neuroticism—and serotonin 5-HT1A receptor binding potential. METHOD: Positron emission tomography with [11C]WAY-100635 was ...
https://doi.org/10.1176/appi.ajp.158.8.1326Letter to the Editor
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Book Forum: Psychotherapies
Book Forum: Cognition and Memory
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