American Journal of Psychiatry
- Volume 159
- Number 4
- April 2002
Editorial
Reviews and Overviews
Publication date: 01 April 2002
Pages519–526Vincent van Gogh (1853–1890) had an eccentric personality and unstable moods, suffered from recurrent psychotic episodes during the last 2 years of his extraordinary life, and committed suicide at the age of 37. Despite limited evidence, well over 150 ...
https://doi.org/10.1176/appi.ajp.159.4.519Images in Neuroscience
Clinical Case Conference
Images in Psychiatry
Article
Publication date: 01 April 2002
Pages539–545OBJECTIVE: Biometrical model fitting was applied to clinical data from twins to investigate whether operationally defined schizophrenic, schizoaffective, and manic syndromes share genetic risk factors. METHOD: Seventy-seven monozygotic and 89 same-sex ...
https://doi.org/10.1176/appi.ajp.159.4.539Publication date: 01 April 2002
Pages546–553OBJECTIVE: Schizophrenia is associated with language-related dysfunction. At the most basic level, the dysfunction of schizophrenic patients in perceiving phoneme boundaries has been demonstrated in a behavioral task. The goal in this study was to obtain ...
https://doi.org/10.1176/appi.ajp.159.4.546Publication date: 01 April 2002
Pages554–560OBJECTIVE: Maintenance medication is critical in the prevention of psychotic relapse and rehospitalization among patients with schizophrenia. Given potential adverse effects, identification of the minimum effective dose is clinically important. METHOD: A ...
https://doi.org/10.1176/appi.ajp.159.4.554Association of Diabetes Mellitus With Use of Atypical Neuroleptics in the Treatment of Schizophrenia
Publication date: 01 April 2002
Pages561–566OBJECTIVE: The development of both type I and type II diabetes after initiation of some atypical neuroleptics has been reported, primarily in studies involving small series of patients. This study used administrative data from a large national sample of ...
https://doi.org/10.1176/appi.ajp.159.4.561Publication date: 01 April 2002
Pages567–572OBJECTIVE: This study aimed to examine the extent and type of variation in antipsychotic prescription patterns between African American and Caucasian patients with schizophrenia. METHOD: Subjects were 2,515 adult Medicaid recipients treated for ...
https://doi.org/10.1176/appi.ajp.159.4.567Publication date: 01 April 2002
Pages573–584OBJECTIVE: A central ethical issue in schizophrenia research is whether participants are able to provide informed consent, particularly for protocols entailing medication washouts or placebo treatments. Few data show how patients with schizophrenia and ...
https://doi.org/10.1176/appi.ajp.159.4.573Publication date: 01 April 2002
Pages585–591OBJECTIVE: The authors’ goal was to assess healthy individuals’ attitudes toward five of the most prominent proposed safeguards regarding the consent process for research with adults unable to consent. METHOD: Telephone interviews were conducted with 246 ...
https://doi.org/10.1176/appi.ajp.159.4.585Publication date: 01 April 2002
Pages592–598OBJECTIVE: The occurrence, persistence and specificity of the association between comorbid obsessive-compulsive and panic symptoms and three psychotic disorders—schizophrenia/schizoaffective disorder, bipolar disorder with psychosis, and major depression ...
https://doi.org/10.1176/appi.ajp.159.4.592Publication date: 01 April 2002
Pages599–606OBJECTIVE: Lesions of the medial prefrontal cortex and dysfunctions in serotonin turnover are two well-established factors associated with impulsive and sociopathic behaviors, but no firm neuroanatomical data have linked these pathophysiological findings. ...
https://doi.org/10.1176/appi.ajp.159.4.599Publication date: 01 April 2002
Pages607–614OBJECTIVE: Family functioning and peer influences are theoretically linked to child psychopathology. This study quantified the functional status of families with fathers with substance dependence with or without comorbid antisocial personality disorder ...
https://doi.org/10.1176/appi.ajp.159.4.607Publication date: 01 April 2002
Pages615–619OBJECTIVE: The goal of this study was to examine the relationship between suicide and substance use among completed suicides in Fulton County, Ga., from 1994 through 1998. METHOD: Extensive data on completed suicides were obtained from records of the ...
https://doi.org/10.1176/appi.ajp.159.4.615Publication date: 01 April 2002
Pages620–629OBJECTIVE: This study examined risk factor profiles of pure and comorbid 12-month mood, anxiety, and substance use disorder in the general population. METHOD: Data were derived from the Netherlands Mental Health Survey and Incidence Study, a prospective ...
https://doi.org/10.1176/appi.ajp.159.4.620Publication date: 01 April 2002
Pages630–636OBJECTIVE: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter ...
https://doi.org/10.1176/appi.ajp.159.4.630Publication date: 01 April 2002
Pages637–643OBJECTIVE: The authors provide a detailed clinical description of minor depression: its symptoms, level of disability, stability, and relationship to patient and family history of major depressive disorder. METHOD: Rigorous criteria for minor depression, ...
https://doi.org/10.1176/appi.ajp.159.4.637Publication date: 01 April 2002
Pages644–651OBJECTIVE: This study examined the frequency of negative and positive symptoms in nonpsychotic patients with temporal lobe epilepsy and the relationship of negative and positive symptoms to cognition, quantitative magnetic resonance imaging (MRI) ...
https://doi.org/10.1176/appi.ajp.159.4.644Brief Report
Publication date: 01 April 2002
Pages652–654OBJECTIVE: In the prefrontal cortex, the enzyme catechol O-methyltransferase (COMT) is critical in the metabolic degradation of dopamine, a neurotransmitter hypothesized to influence human cognitive function. The COMT gene contains a functional ...
https://doi.org/10.1176/appi.ajp.159.4.652Publication date: 01 April 2002
Pages655–657OBJECTIVE: Metformin was assessed as a treatment for weight gain in children taking olanzapine, risperidone, quetiapine, or valproate. METHOD: The subjects were 19 patients aged 10–18 years; 15 were white and four were black, and there were 12 boys and ...
https://doi.org/10.1176/appi.ajp.159.4.655Publication date: 01 April 2002
Pages657–660OBJECTIVE: An animal model was used to investigate an autoimmune etiology for some cases of Tourette’s syndrome. METHOD: Sera from 12 patients with Tourette’s syndrome with high levels of antineural or antinuclear antibodies were infused bilaterally into ...
https://doi.org/10.1176/appi.ajp.159.4.657Publication date: 01 April 2002
Pages660–663OBJECTIVE: The purpose of this study was to examine potential differences in measures of trauma-related phenomena between subjects with pseudoseizures and subjects with intractable epilepsy. METHOD: Thirty-one adult subjects with pseudoseizures and 32 ...
https://doi.org/10.1176/appi.ajp.159.4.660Publication date: 01 April 2002
Pages663–665OBJECTIVE: Studies have demonstrated low concentrations of γ-aminobutyric acid (GABA) in the plasma and CSF of individuals with major depression, and low GABA concentrations have also been found in the occipital cortex of depressed subjects. The goal of ...
https://doi.org/10.1176/appi.ajp.159.4.663Publication date: 01 April 2002
Pages666–669OBJECTIVE: About 5% of pregnant women meet criteria for major depression. No pharmacotherapy is specifically approved for antepartum depression; novel treatment approaches may be welcome. The authors explored the use of morning bright light therapy for ...
https://doi.org/10.1176/appi.ajp.159.4.666Ødegaard’s Selection Hypothesis Revisited: Schizophrenia in Surinamese Immigrants to the Netherlands
Publication date: 01 April 2002
Pages669–671OBJECTIVE: The incidence of schizophrenia among Surinamese immigrants to the Netherlands is high. The authors tested Ødegaard’s hypothesis that this phenomenon is explained by selective migration. METHOD: The authors imagined that migration from Surinam ...
https://doi.org/10.1176/appi.ajp.159.4.669Letter to the Editor
Book Forum: The Schizophrenia Spectrum
Book Forum: Posttraumatic Stress
Book Forum: Anger/Hostility/Violence
Book Forum: Sexuality
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